时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
Hematopoietic stem cells (HSCs) maintain their function through interactions with niche cells in the bone marrow. We previously demonstrated that protection of telomeres 1a (Pot1a), a shelterin component, maintains HSCs and neuron-glial antigen 2-expressing (NG2+) mesenchymal stem cells (MSCs) by suppressing DNA damage response (DDR) and reactive oxygen species (ROS) production. However, the role of Pot1a in leptin receptor-expressing (LepR+) MSCs, a primary HSC niche component, remains unclear. LepR-specific Pot1a knockout mice showed decreased LepR+ MSC numbers, increased DDR and ROS production, reduced HSC quiescence, and impaired long-term hematopoietic reconstitution. In contrast, cell-…
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原文题录
- 中文题名：Pot1a 维持间充质干细胞微环境功能以支持造血干细胞
- 英文标题：Pot1a maintains mesenchymal stem cell niche function to support hematopoietic stem cells.
- 期刊与标识：Cell Rep · PMID 42965868 · DOI 10.1016/j.celrep.2026.118240 · EDAT 2026-10-31