时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
We hypothesized that oncologic surgery would amplify the adverse association between reduced physiological reserve and early postoperative outcomes.
方法
Participants were consecutively enrolled between January 2023 and June 2025 at participating surgical centers.
核心结论
Rather, the clinically dominant pattern was a higher baseline risk associated with oncologic surgery superimposed on a broadly adverse gradient of reduced reserve.；In the additional adjusted ordinal main-effects model, each increment from fit to pre-frail or from pre-frail to frail was associated with higher odds of prolonged LOS (OR 2.91, 95% CI 1.57–5.38; p < 0.001).；HGS was not associated with the outcome in the non-oncologic stratum (OR 0.995 per kg, 95% CI 0.894–1.107; p = 0.926) but was inversely associated in the oncologic stratum (OR 0.928, 95% CI 0.874–0.985; p = 0.013) ( ).；HGS was statistically associated with prolonged LOS only in the oncologic stratum, whereas the frailty OR appeared numerically larger in non-oncologic surgery.
局限
Future studies should prespecify interaction hypotheses, recruit sufficient events within each surgical context, retain center identifiers, and quantify operative stress more granularly.；Effect modification is scale-dependent ( ); therefore, the lack of evidence of multiplicative interaction should not be interpreted as absence of all clinically relevant heterogeneity.
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：功能结局（衰弱 / 肌少症）是临床转化最可及的终点，适合作为一期终点候选。 ｜ 价值分 1.0/5（★☆☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 26,013 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Physiological reserve and early recovery across oncologic and non-oncologic abdominal surgery: a prospective multicenter interaction analysis.
- 期刊与标识：Frontiers in oncology · PMID 42959058 · DOI 10.3389/fonc.2026.1954486
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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