时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Furthermore, it remains inconclusive whether the observed changes in the microbiota have a causal relationship with the therapeutic effects.Honokiol (HKL) is a naturally occurring biphenolic compound found in Magnolia officinalis Rehder & E.H.Wilson (Magnoliaceae), possessing anti-inflammatory, antioxidant, and mucosal protective effects.；However, this study did not include a positive drug control group, nor did it conduct experiments to verify whether PPARγ is functionally essential for these effects.；Since no PPARγ-specific pharmacological or genetic interference experiments were conducted, nor were any direct target binding assays performed, it remains unclear whether PPARγ plays a functional role in the protective effects of LEBG.Licorice flavonoid extract (LF), derived from the roots of G. uralensis Fisch. ex DC.
方法
Aminosalicylic acid-based drugs are suitable for patients with mild to moderate disease but have limited efficacy in the treatment of moderate to severe active disease; long-term use of glucocorticoids can lead to serious adverse reactions such as osteoporosis, infections, and metabolic disorders (De Deo et al., 2024).；Immunosuppressants take time to take effect and carry risks such as bone marrow suppression and liver and kidney damage; although biologics have significantly improved the prognosis of moderate-to-severe UC, a considerable proportion of patients still experience primary or secondary non-response, and the high cost of treatment limits their widespread use (Kazemifard et al., 2025).；Subsequently, PPARγ-related mechanisms were classified according to their level of evidence, including PPARγ expression regulation, molecular docking predictions, pharmacological blockade/rescue experiments, direct binding or transcriptional activity assays, and genetic evaluation.
核心结论
These pathological changes are interlinked and collectively maintain a state of persistent inflammation in the intestinal mucosa (Hanzel et al., 2022).；These findings support the functional involvement of PPARγ-related signaling pathways in the anti-inflammatory effects of paeonol.；Therefore, while the available evidence establishes an association between GRb1 treatment and PPARγ-related molecular changes, it is insufficient to demonstrate that PPARγ is functionally essential for GRb1’s action or is directly targeted by GRb1.18β-Glycyrrhetinic acid (18β-GA) is a triterpenoid associated with the constituents of Glycyrrhiza uralensis Fisch. ex DC.
局限
However, existing studies still have significant shortcomings in terms of the specificity of target evaluation, limitations of animal models, lack of pharmacokinetic data, and insufficient evidence for clinical translation.；(2026) 0,3,6,12,24,48 μMRAW264.7 cellsCrassula tetragona L------200,400 mg/kgUC modelTNF-α↓IL-6↓IL-10↑SOD↑GSH↑MDA↓Inhibiting intestinal inflammation and oxidative imbalanceIt is not possible to clearly identify direct interactions between phenolic bioactive molecules and PPARγ/SIRT1 proteins, and there are significant limitations in elucidating the mechanisms of action at the molecular target level Raslan et al.；However, since the direct binding of the compound to PPARγ and receptor activation were not evaluated, the current evidence only supports a PPARγ-dependent mechanism rather than establishing PPARγ as a direct molecular target of emodin.Paeonol is a naturally occurring phenolic compound found in Paeonia × suffruticosa Andrews (Paeoniaceae) and exhibits anti-inflammatory, antioxidant, and immunomodulatory properties.
对本项目的价值
中高价值：属「营养感知—自噬—蛋白稳态轴」方向；mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.1/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 102,852 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：PPARγ 通路：天然化合物治疗溃疡性结肠炎的策略与局限
- 英文标题：PPARγ signaling pathway: strategies and limitations of natural compounds in the treatment of ulcerative colitis.
- 期刊与标识：Frontiers in pharmacology · PMID 42978878 · DOI 10.3389/fphar.2026.1977683 · PMC PMC13728434