时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
The three living states were defined according to whether participants reported frequent pain located in the back and, if so, its severity.；Based on previous evidence, we hypothesized that greater chronic disease burden would be associated with higher hazards of low back pain onset and worsening, lower hazards of recovery, and higher hazards of death.；Definition of low back pain states Low back pain states were operationalized at each wave using HRS questionnaire items on whether respondents were frequently troubled by pain, the location of the pain, and the reported overall pain severity.
方法
Thus, cross-sectional analyses and binary outcome models may fail to capture the dynamic processes of onset, progression, recovery, and death [ 10 , 11 ].；The HRS is a nationally representative longitudinal cohort of middle-aged and older adults in the United States.；Interview records collected when participants were aged 60 years or younger were excluded, whereas participants could enter the analytic cohort at their first subsequent interview after age 60.
核心结论
Together, these findings suggest that chronic disease burden may contribute to a less favorable course of low back pain.；These findings suggest that low back pain in older adults is not merely a localized musculoskeletal condition [ 25 ], but often coexists with accumulated chronic disease, functional decline, and poor mental health [ 26 ].
局限
In older adults, low back pain is associated with impaired quality of life, activity limitation, functional decline, depressive symptoms, greater health care use, and increased mortality risk [ 3 – 5 ].；Multimorbidity is prevalent among older adults [ 12 , 13 ] and may influence the course of low back pain through pathways involving chronic inflammation, metabolic dysregulation, reduced physical activity, muscle weakness, functional limitation, and psychological burden [ 14 , 15 ].
对本项目的价值
参考价值：属「生物标志物 / 建模方法学」方向；其他衰老相关栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 42,468 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：多重慢病与老年人腰痛状态的动态转移：HRS 多状态马尔可夫分析
- 英文标题：Multimorbidity and dynamic transitions of low back pain states in older adults: a multistate markov analysis of the health and retirement study.
- 期刊与标识：BMC Geriatr · PMID 42966862 · DOI 10.1186/s12877-026-08148-5 · PMC PMC13723127 · EDAT 2026-11-01