时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
This makes it difficult to determine whether observed subtype‐specific patterns represent reproducible disease‐related differences or features of a particular data source, recruitment setting or follow‐up structure.；6 , 7 , 8 Differences in case‐mix, diagnostic workflow and assessment density between these resources create an opportunity to examine which MMSE‐based trajectory findings are stable across settings and which are dependent on cohort structure.；The primary aim was to determine whether relative patterns of cognitive decline across dementia subtypes were reproducible across two complementary longitudinal data resources.
方法
Most longitudinal studies of cognitive decline rely on a single cohort.；6 , 7 , 8 Differences in case‐mix, diagnostic workflow and assessment density between these resources create an opportunity to examine which MMSE‐based trajectory findings are stable across settings and which are dependent on cohort structure.；A secondary aim was to examine whether absolute long‐horizon decline estimates differed according to cohort follow‐up structure and time‐model specification.
核心结论
20 Taken together, these findings provide reference patterns for future studies using SveDem, NACC or other longitudinal dementia cohorts.
局限
3 , 4 , 5 However, MMSE is a brief and bounded scale.；The study was intended to provide cross‐cohort reference patterns for future studies using MMSE trajectories to compare dementia subtypes, examine clinical factors or evaluate treatment‐related associations.
对本项目的价值
中等价值：属「脑老化与认知轨迹」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.5/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 31,061 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：不同痴呆亚型的 MMSE 轨迹：瑞典 SveDem 与美国 NACC 队列比较
- 英文标题：Mini-Mental State Examination trajectories across dementia subtypes in the Swedish Registry for Cognitive/Dementia Disorders and U.S. National Alzheimer's Coordinating Center.
- 期刊与标识：Alzheimers Dement (Amst) · PMID 42967021 · DOI 10.1002/dad2.70531 · PMC PMC13722606 · EDAT 2026-11-01