时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
BackgroundHearing loss (HL) is a potent, modifiable risk factor for Alzheimer's disease (AD), but the underlying molecular mechanisms remain elusive. microRNAs (miRNAs) are potential key mediators given their roles in both neurodegeneration and auditory function.ObjectiveTo investigate whether peripheral blood miRNA profiles differ between AD patients with and without HL, and whether hsa-miR-6875-5p serves as a candidate molecular link.MethodsIn a case-control study of 41 AD patients (AD-HL n = 24, AD-non-HL n = 17), we performed neuropsychological assessments, plasma miRNA sequencing, target gene prediction, and external validation using public transcriptomic datasets.ResultsAD-HL patients …
对本项目的价值
参考价值：属「脑老化与认知轨迹」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文不可及原因
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原文题录
- 中文题名：临床与转录组整合分析揭示听力损失与阿尔茨海默病认知衰退的 miRNA 机制
- 英文标题：Integrated clinical and transcriptomic analysis reveals miRNA-mediated mechanisms linking hearing loss to cognitive decline in Alzheimer's disease.
- 期刊与标识：J Alzheimers Dis · PMID 42968239 · DOI 10.1177/13872877261501149 · EDAT 2026-11-01