时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
The present study aims to combine population-based investigations, animal models, and cross-sectional clinical research to clarify the influence of high-altitude environments on PD pathogenesis.；Results PD prevalence in a high-altitude population and motor deficits in high-altitude A53T mice To investigate the potential impact of high-altitude hypoxia on the progression of PD, we initially conducted an epidemiological survey among middle-aged and elderly residents (≥ 45 years) in Shigatse, Tibet (3,800 m).；A two-tailed independent t test was used for normally distributed data, whereas nonnormally distributed data were analyzed via the Mann‒Whitney U test after the Kolmogorov‒Smirnov test was performed To investigate the effects of altitude, we maintained 4-month-old A53T transgenic mice under high-altitude and low-altitude control conditions.
方法
The present study aims to combine population-based investigations, animal models, and cross-sectional clinical research to clarify the influence of high-altitude environments on PD pathogenesis.；Methods Epidemiological investigation and PD diagnosis From January to June 2022, we administered a cross-sectional survey targeting middle-aged and elderly populations (≥ 45 years) in rural communities of Shigatse City, Tibet Autonomous Region (altitude: 3,800 m).；A total of 665 eligible participants were enrolled.
核心结论
Notwithstanding this limitation, these findings suggest that chronic high‑altitude residence may be associated with a higher prevalence of PD.；These results suggest that chronic hypoxic exposure may accelerate Parkinsonian motor dysfunction.；Taken together, these findings collectively suggest that the synergistic dysregulation of immune-inflammatory responses and oxidative stress may contribute to BBB impairment in high-altitude PD pathogenesis.
局限
However, the two estimates are not directly comparable, as the national report does not provide age‑standardized prevalence data specific to the population aged 40 years and older.；Notwithstanding this limitation, these findings suggest that chronic high‑altitude residence may be associated with a higher prevalence of PD.
对本项目的价值
参考价值：属「衰老机制与老年临床」方向；方法学 / 生物标志物 / AI 建模栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 41,690 字符，题名指纹 0.64，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：高原环境升高中枢与外周 α-突触核蛋白水平并加速帕金森病相关病理
- 英文标题：High-altitude environments elevate central and peripheral α-synuclein levels and accelerate PD-related pathology.
- 期刊与标识：J Transl Med · PMID 42963787 · DOI 10.1186/s12967-026-09103-z · PMC PMC13723142 · EDAT 2026-10-31