时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
摘要（PubMed 原文节选）
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains largely incurable because of its marked cellular heterogeneity, limited drug delivery, and rapid development of resistance to temozolomide (TMZ). Beyond its cytotoxic activity, TMZ induces genotoxic and oxidative stress and exerts strong selective pressure…
对本项目的价值
参考价值：属「衰老细胞清除 / SASP 轴」方向；细胞衰老 / senolytics / SASP栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.8/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 Europe PMC / OpenAlex / Unpaywall 未提供可下载 OA 全文
原文题录
- 中文题名：化疗压力下的胶质母细胞瘤：塑造肿瘤行为与耐药的肿瘤细胞适应性互联网络
- 英文标题：Glioblastoma under chemotherapy pressure: interconnected tumor-cell adaptations shaping tumor behaviour and resistance.
- 期刊与标识：Biochimica et biophysica acta. Reviews on cancer · PMID 42977098 · DOI 10.1016/j.bbcan.2026.189746