时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
AIMS: This study aimed to characterize regional cerebral blood flow (CBF) alterations in behavioral variant frontotemporal dementia (bvFTD), examine their associations with clinical symptoms and peripheral vascular/synaptic biomarkers, evaluate spatial concordance with gray matter volume (GMV) loss and glucose hypometabolism, and explore CBF's mediating role between biomarkers and clinical outcomes. METHODS: Thirty-five bvFTD patients and 27 matched normal controls (NC) underwent clinical assessments, ASL MRI, 18F-FDG PET, and structural MRI. Plasma vascular (VEGFA, PDGF-BB) and synaptic (NPTXR, NPTX2) biomarkers were measured via the Olink platform. Statistical analyses included group compa…
对本项目的价值
参考价值：属「脑老化与认知轨迹」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 OpenAlex / Unpaywall 未提供可下载 OA PDF
原文题录
- 中文题名：行为变异型额颞叶痴呆的额叶脑血流缺损：症状、外周血管标志物与影像关联
- 英文标题：Frontal Cerebral Blood Flow Deficits in Behavioral Variant Frontotemporal Dementia: Associations With Clinical Symptoms, Peripheral Vascular Biomarkers, and Neuroimaging Measures.
- 期刊与标识：CNS Neurosci Ther · PMID 42968588 · DOI 10.1002/cns.71235 · EDAT 2026-11-02