时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Geroscience investigates whether targeting fundamental mechanisms of aging can delay age-related diseases and preserve physiological resilience.；Whether these aging-related mechanisms substantially contribute to the clinical benefits of established HF therapies in humans remains uncertain.；An important question is whether skeletal muscle dysfunction merely reflects advanced HF or actively contributes to its progression.
方法
In the OPTIMISE HFpEF cohort, frailty was associated with a more than fourfold higher risk of the one-year composite endpoint of all-cause hospitalization or death [ 7 ].；In 8,558 participants from the PREVEND cohort followed for 25 years, hypertension, hypercholesterolemia, obesity, smoking, atrial fibrillation, chronic kidney disease, myocardial infarction, and type 2 diabetes collectively accounted for approximately 46–71% of incident HF cases, depending on sex and HF phenotype.；Clinical (interventional): The Q-SYMBIO trial suggested a potential benefit of CoQ10 supplementation in chronic HF; however, the study was relatively small and was conducted before the widespread implementation of contemporary foundational medical therapy [ 26 ].
核心结论
In 8,558 participants from the PREVEND cohort followed for 25 years, hypertension, hypercholesterolemia, obesity, smoking, atrial fibrillation, chronic kidney disease, myocardial infarction, and type 2 diabetes collectively accounted for approximately 46–71% of incident HF cases, depending on sex and HF phenotype.；These findings indicate that frail patients may derive comparable relative, and potentially greater absolute, benefit from effective therapy.
局限
Given its high prevalence, prognostic relevance, and potential modifiability, routine frailty screening should be considered in all patients with HF aged ≥ 70 years, irrespective of ejection fraction or care setting.；Clinical (interventional): The Q-SYMBIO trial suggested a potential benefit of CoQ10 supplementation in chronic HF; however, the study was relatively small and was conducted before the widespread implementation of contemporary foundational medical therapy [ 26 ].
对本项目的价值
中等价值：属「衰老细胞清除 / SASP 轴」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 39,014 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：老年心力衰竭患者的衰弱
- 英文标题：Frailty in Older Adults with Heart Failure.
- 期刊与标识：Curr Heart Fail Rep · PMID 42965803 · DOI 10.1007/s11897-026-00785-6 · PMC PMC13723665 · EDAT 2026-10-31