时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Therefore, this propensity score-matched study was designed to evaluate the effect of esketamine as a perineural adjuvant to ropivacaine in PENG blocks on early postoperative recovery quality and analgesia in elderly patients undergoing hip fracture surgery.；We hypothesized that the addition of esketamine would enhance the quality of early postoperative recovery, prolong the duration of sensory blockade, and improve postoperative pain control and sleep quality, without incurring a significant increase in adverse events.；Ultimately, this approach aims to provide a refined regional analgesia strategy that effectively balances efficacy and safety, thereby supporting enhanced recovery after surgery (ERAS) protocols in the geriatric hip fracture population.
方法
3 Moreover, the intense pain evoked by hip fractures profoundly influences postoperative recovery, length of hospital stay, and long-term quality of life in this susceptible cohort.；Materials and Methods Study Design and Data Sources This single-center, retrospective cohort study was conducted at Xuzhou Renci Hospital between July 2024 and May 2025.；After tracheal intubation, an ultrasound-guided PENG block was performed.
核心结论
2 Advanced age is frequently accompanied by multisystem degenerative comorbidities—involving the cardiovascular, respiratory, and renal systems—which collectively pose substantially elevated anesthetic and surgical risks.；In the univariate screening stage (with an entry threshold of P < 0.10), age, sex, aCCI, prior surgical history, preoperative anxiety levels, preoperative sleep quality, and frailty status were significantly associated with unfavorable trajectory assignment.；Sensitivity Analyses for Model Robustness At 24 h, esketamine significantly improved QoR-15 (Model 1: β = 8.50; P < 0.001), PSQI (β = 4.00; P < 0.001), and VAS (β = 1.00; P < 0.001), with consistent findings across Models 2 and 3 (all P < 0.001).
局限
4 Consequently, the optimization and selection of perioperative management strategies for this fragile patient population constitute a critical clinical priority that warrants prudent and comprehensive evaluation.；Thus, the study could detect small-to-moderate effects, but smaller effects cannot be excluded.
对本项目的价值
参考价值：属「衰弱 / 肌少症功能结局」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.1/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 48,191 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：艾司氯胺酮作为罗哌卡因佐剂用于老年髋部骨折 PENG 阻滞：倾向评分匹配回顾队列
- 英文标题：Esketamine as a Perineural Adjuvant to Ropivacaine for Pericapsular Nerve Group (PENG) Block in Elderly Patients Undergoing Hip Fracture Surgery: A Propensity Score-Matched Retrospective Cohort Study.
- 期刊与标识：Drug Des Devel Ther · PMID 42967015 · DOI 10.2147/DDDT.S641258 · PMC PMC13722614 · EDAT 2026-11-01