时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the therapeutic mechanisms of ESK in the specific context of neuropathic pain-related depression remain insufficiently explored.；Crucially, the precise endogenous gene programs, such as specific post-transcriptional and translational modification networks, through which ESK remodels the ACC microenvironment during comorbidity alleviation remain largely unknown ().；However, whether ESK treatment mitigates PDD pathology by modulating ACC transcriptomic profiles and Wnt4-associated signaling components remains to be systematically investigated.
方法
Healthy male Sprague–Dawley rats (specific pathogen-free, aged 6–8 weeks, weighing 180–220 g) were used in this investigation.；All experimental protocols were formally approved by the Animal Care and Use Committee of the Affiliated Hospital of Zunyi Medical University (Approval No. zyfy-an-2025-0694).；The detailed experimental allocation, sample sizes (n) for each group across various biochemical and behavioral assays, and biological replicate specifications are comprehensively summarized in .；Downstream evaluations followed a staggered chronological schedule to isolate sustained behaviors from transient acute confounds ().
核心结论
In parallel, longitudinal tracking showed that TWL and MWT were markedly reduced over the 21-day modeling period ().；Concurrently, during the pre-injection baseline screenings, the modeling cohort displayed significant depression-like phenotypes on days 19 and 20, characterized by decreased total locomotor distance and reduced time spent in the central zone during the OFT, a diminished sucrose preference index, and a prolonged immobility time in the FST ().；These findings confirm that by day 21 after CCI, the rats developed robust mechanical and thermal hyperalgesia tightly coupled with stable depression-like behaviors. ‖ 结论：Collectively, this work provides supportive multi-level evidence for cortical molecular characterization in pain-related affective disorders and highlights a candidate signaling pathway for future therapeutic exploration.
局限
On the other hand, transcriptomic annotation revealed a profound disturbance in neuroactive ligand-receptor interactions, a signature implying a generalized homeostatic and signaling imbalance within the central nervous system during comorbidity development ().
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
全文来源
PMC JATS 全文（正文 52,912 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Esketamine alleviates the pain-depression dyad: insights from exploratory transcriptomic profiling and Wnt4-associated molecular alterations within the anterior cingulate cortex.
- 期刊与标识：Front Pharmacol · PMID 42964278 · DOI 10.3389/fphar.2026.1873924
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