时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
PWV decomposition was therefore used as a complementary approach to examine whether the prior cfPWV × NfL pattern was more apparent for S–PWV, LD–PWV, or both.RESEARCH IN CONTEXT Systematic review: Previous studies suggest that higher arterial stiffness may exacerbate associations between neurodegenerative biomarkers and cognition, but the composite nature of carotid–femoral pulse wave velocity has limited insight into whether these relationships are more closely aligned with structural arterial remodeling or load‐dependent hemodynamic influences.；Future directions: Longitudinal studies are needed to define temporal relationships among arterial stiffening, NfL, and cognitive decline, and to determine whether interventions targeting vascular remodeling modify dementia risk or neurodegenerative trajectories.This distinction may also be cognitively relevant because brain regions differ in susceptibility to vascular and neurodegenerative processes.；Whether vascular–neurodegenerative coupling differs between S–PWV and LD–PWV across these domains is unknown.We tested whether plasma NfL interacts with S–PWV and LD–PWV components of cfPWV in relation to domain‐specific cognitive performance in cognitively unimpaired older adults.
方法
Prior research from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) cohort demonstrated that higher conventional cfPWV strengthened associations between higher plasma NfL and poorer cognitive performance. 19 Because cfPWV reflects both intrinsic arterial wall properties and load‐dependent hemodynamic conditions, the component most aligned with this pattern remained unclear.；Whether vascular–neurodegenerative coupling differs between S–PWV and LD–PWV across these domains is unknown.We tested whether plasma NfL interacts with S–PWV and LD–PWV components of cfPWV in relation to domain‐specific cognitive performance in cognitively unimpaired older adults.；Given prior evidence linking structural stiffness to cognitive decline, brain atrophy, and WMH burden, 8 we hypothesized that NfL–cognition associations would be stronger at higher levels of S–PWV, particularly for processing speed and executive/attentional control domains that are sensitive to white matter and microvascular injury.
核心结论
Prior research from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) cohort demonstrated that higher conventional cfPWV strengthened associations between higher plasma NfL and poorer cognitive performance. 19 Because cfPWV reflects both intrinsic arterial wall properties and load‐dependent hemodynamic conditions, the component most aligned with this pattern remained unclear.；PWV decomposition was therefore used as a complementary approach to examine whether the prior cfPWV × NfL pattern was more apparent for S–PWV, LD–PWV, or both.RESEARCH IN CONTEXT Systematic review: Previous studies suggest that higher arterial stiffness may exacerbate associations between neurodegenerative biomarkers and cognition, but the composite nature of carotid–femoral pulse wave velocity has limited insight into whether these relationships are more closely aligned with structural arterial remodeling or load‐dependent hemodynamic influences.；However, these findings did not survive false discovery rate correction and should be interpreted as preliminary evidence that chronic arterial remodeling may contribute to neuroaxonal injury–related cognitive vulnerability.
局限
However, these findings did not survive false discovery rate correction and should be interpreted as preliminary evidence that chronic arterial remodeling may contribute to neuroaxonal injury–related cognitive vulnerability.；However, the S–PWV findings did not survive FDR correction, and continuous interaction models were non‐significant; therefore, they should be interpreted as preliminary and hypothesis generating rather than definitive component‐specific moderation.；However, source documentation did not permit independent verification of original path‐length entries for all unusually low values.
对本项目的价值
中等价值：属「脑老化与神经退行」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 42,505 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：分解的动脉硬度与 NfL-认知关联在老年人中的表现：IGNITE 研究
- 英文标题：Decomposed arterial stiffness and NfL-cognition association in older adults: The IGNITE study.
- 期刊与标识：Alzheimer's & dementia (Amsterdam, Netherlands) · PMID 42979025 · DOI 10.1002/dad2.70507 · PMC PMC13728322