时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Despite recent advances in cancer treatment, glioblastoma (GBM) remains a public health issue, given its aggressiveness and high morbidity ().；However, in GBM, immunotherapy has yielded little improvement in overall survival ().；However, in the case of chronic stress, SGs tend to exhibit pathological features (; ).
方法
Overall survival time (OS_MONTHS) was calculated from days to death (for deceased patients) or to last follow-up (for censored patients) and converted to months.；Given the absence of some patient information on molecular features, we performed a multivariate Cox analysis with MGMT status (n = 227/287), Karnofsky performance score (n = 217/287), transcriptomic subtype (n = 250/287), and IDH mutation status (n = 268/287) (n = 140 complete cases).；Using DZIP3 expression (continuous, z-score standardized) as the primary predictor, we performed univariable Cox proportional hazards regression.；We later adjusted for age at diagnosis (z-score standardized), sex, MGMT promoter methylation status, Karnofsky performance score, transcriptomic subtype, and IDH mutation status (n = 140 for the complete cases) in the multivariable model.
核心结论
High DZIP3 expression was associated with prolonged overall survival compared with patients with low DZIP3 expression (p < 0.05).；We observed that HR < 1, indicating that higher DZIP3 expression is associated with a better prognosis, although the effect is not statistically significant.；The results confirm the previous outcomes of the univariate Cox analysis: DZIP3 is not significantly associated with survival (HR = 1.08, 95%CI:0.75–1.6, p = 0.66). ‖ 结论：Our findings characterize DZIP3 as a transcriptional associate of harmonized intracellular transport and biosynthetic activity.
局限
The therapeutic resistance to standard treatments could be explained by GBM microenvironmental heterogeneity, in which a dynamic interplay among immune, stromal, and tumor cells is key to cancer progression ().；These correlations persisted even after controlling for confounding factors (partial ρ = 0.51), in the validation cohort (CGGA, ρ = 0-58-0.81), and at single-cell resolution in malignant cells from an independent GBM atlas (GBMCore, partial ρ = 0.11, controlling for sequencing depth).；This suggests that these signatures may not be artifacts but may encompass overlapping biology.
对本项目的价值
★☆☆☆☆ 相关范围内，作为背景与横向对照收录。设计 single-cell。
全文来源
PMC JATS 全文（正文 56,724 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation.
- 期刊与标识：Front Bioinform · PMID 42959642 · DOI 10.3389/fbinf.2026.1878616
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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