时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
These movement detriments, such as shortened stride lengths or impaired balance during locomotion, have been shown to result from these individuals’ reduced ability to flexibly adapt their locomotion patterns in response to challenges or constraints in their environment ().；However, conflicting findings preclude an adequate interpretation of corticospinal behaviour in older adults as some authors observed decreased corticospinal excitability (; ) while others suggested no age-related changes ().；Nonetheless, the extent to which changes in stride-to-stride temporal dynamics are linked to alterations in cortical and corticospinal inputs remains unclear.
方法
Participants were excluded if they had any neurological or neuromuscular disorders, implanted medical devices (e.g., cardiac pacemakers, cochlear implants, or medical pumps), were taking medications that could affect nervous system function or presented any other contraindications to the use of transcranial magnetic stimulation (TMS) technique.；Prior to participating in the experimental procedures, all individuals provided written informed consent and completed a TMS safety screening questionnaire ().；Participants were asked to visit the laboratory on one occasion for an experimental session with a duration of ∼1 h.；Participants were instructed to arrive at the laboratory well hydrated, abstain from alcohol for 24 h, and avoid strenuous physical activity for 48 h before the experimental session.
核心结论
The model’s residuals followed a normal distribution (p = 0.207) and exhibited constant variance across all levels of independent variables (p = 0.104).；Multicollinearity of predictors was not present (CSE = 1.039, SP = 1.015, SICI = 1.037) and further analysis also showed errors to be independent from each other (D-W = 2.19).；The overall model based on was not statistically significant, F(3, 28) = 0.20, p = 0.895, explaining R 2 = 0.021 (adjusted R 2 = −0.084) of the variance in αISIS. ‖ 结论：The regulation of gait variability likely reflects the integrated function of spinal, cortical and subcortical networks, as well as peripheral sensory feedback, whose interactions collectively shape locomotor adaptability.
局限
It appears that the involvement of the corticospinal tract in movement regulation remains a topic of considerable debate, underscoring the need for further research, particularly of studies exploring diverse motor tasks, different muscles of interest, and employing longitudinal designs, aimed at strengthening the robustness and generalizability of current conclusions.；Thus, our findings raise the possibility that the regulation of gait adaptability in highly automated walking tasks may rely less on corticospinal mechanisms, warranting a broader investigation of other neural structures and connections.；Thus, a deeper understanding of the mechanisms underlying gait adaptability is essential an
对本项目的价值
★☆☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。
全文来源
PMC JATS 全文（正文 37,667 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Corticospinal function does not predict stride-to-stride gait dynamics in older adults.
- 期刊与标识：Front Netw Physiol · PMID 42953356 · DOI 10.3389/fnetp.2026.1946459
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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