时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the common clinical discordance between symptom severity and objective signs suggests that the traditional “aqueous-inflammatory” model does not fully explain the complexity of the disease.；Modern lifestyles and systemic physiological changes present persistent challenges to the structure and function of corneal nerves.；A unified neuropathological framework linking microscopic nerve remodeling, neuroimmune crosstalk, altered sensory processing, aging, and multimodal clinical assessment remains incomplete.
方法
Under physiological conditions, the background discharge activity mediated by TRPM8 is the primary driving force for sustaining basal tear secretion.；In the pathogenesis of DED, neurogenic inflammation forms a self-sustaining vicious cycle through the complex interplay between neuropeptides and immune mediators.；Acoltremon ophthalmic solution 0.003% (formerly AR-15512) was approved by the US FDA in May 2025 for the treatment of the signs and symptoms of dry eye disease in adults (; ).
核心结论
Dry eye disease (DED) illustrates this evolution: early models focused predominantly on aqueous tear deficiency or isolated ocular surface inflammation (; ).；Systemic factors such as sleep deprivation, together with central neuroplastic changes associated with chronic DED, may also disrupt peripheral sensory feedback (; ).；Although neural mechanisms are now recognized as integral to ocular surface homeostasis, many reviews still treat nerve injury mainly as a downstream consequence of tear-film instability or inflammation. ‖ 结论：Future research priorities should focus on breaking the vicious cycle of nerve damage and inflammatory exacerbation, and on achieving long-term homeostatic restoration of corneal nerve function through local microenvironmental modulation (; ) ().
局限
We integrate basic and clinical evidence on sensory transduction, age-related neurodegeneration, neuroimmune signaling, structural and functional assessment, and nerve-directed therapy, with the aim of defining clinically relevant neural phenotypes and identifying priorities for future research.；However, corneal sensation, nerve density, and central neurodegeneration do not show a simple one-to-one relationship and are influenced by age, diabetes, ocular surface inflammation, medication use, and other confounders; these measures should therefore not yet be regarded as disease-specific diagnostic biomarkers.；Together, these biological differences contribute to heterogeneity between sexes rega
对本项目的价值
★☆☆☆☆ 皮肤是唯一可直接局部给药、可活检、可影像量化的器官，最快可验证 senotherapeutic 概念。
全文来源
PMC JATS 全文（正文 24,710 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Pathological remodeling and functional evolution of the corneal nervous system in ocular surface dyshomeostasis.
- 期刊与标识：Front Aging Neurosci · PMID 42953486 · DOI 10.3389/fnagi.2026.1946017
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
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