时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, these architectural maps are often examined in isolation, lacking interrogation across different maps and individuals.；It remains uncertain whether any common or distinct patterns exist among these maps, and if they can offer more reliable and sensitive indicators of functional, behavioral, and developmental relevance.；Technological advances in MRI have made it possible to map architectural correlates in the human cortex in a noninvasive and individual-specific way, and to test whether any key architectural features of the cortex reflect its functional organization (; ; ).
方法
The three large-scale brain imaging studies collect behavioral and multimodal MRI data in healthy participants from 5 to 100 years of age, and thus provide us with opportunities to characterize brain changes across the human lifespans.；The use and analyses were approved by the Institutional Review Boards of Beijing Normal University (No.；After excluding participants with invalid MSM-All registration and those without any rs-fMRI data, we obtained multimodal MRI and behavioral data for 1070 HCP-YA participants (586 females, ages 22–37, S1200 release).；Structural MRI data (0.8 mm isotropic) from 652 HCP-D participants (351 females, ages 5–21) and 725 HCP-A participants (406 females, ages 36–100) were used in this study (Lifespan HCP release 2.0).
核心结论
Specifically, PC1 effectively captures the convergence of cortical thickness and tissue density (i.e., how they vary together), while PC2 represents the spatial divergence from this commonality.；Specifically, gradient 1 (i.e., PC1 map) shows an increase in value as one travels from the fundus of the calcarine sulcus (CS) either dorsally toward the intraparietal sulcus or ventrally into the anterior temporal lobe.；Higher PC1 vertex values correspond to lower tissue density and a thicker cortical sheet (). ‖ 结论：These findings provide a normative benchmark for future work examining how deviations from these shared mesoscale architectural patterns underlie neurological disorders.
局限
Future work can examine if functional arealization at earlier developmental timepoints, as in infancy (), follows this prediction.；Therefore, the extent to which these architectural changes reflect local tissue structure versus connectomic features () should be clarified in future work.；These findings provide a normative benchmark for future work examining how deviations from these shared mesoscale architectural patterns underlie neurological disorders.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
全文来源
PMC JATS 全文（正文 44,429 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan.
- 期刊与标识：Elife · PMID 42960830 · DOI 10.7554/elife.102095
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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