时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Hip fracture represents a longstanding and significant public health challenge, particularly in China, where rapid population aging has amplified it’s impacts.；However, the treatment of hip fractures is costly and associated with poor prognoses [–].；The burden imposed on healthcare systems and social services by hip fractures poses a formidable challenge.
方法
CHARLS targets Chinese individuals aged 45 years and older, along with their spouses, covering a broad range of domains including demographic information, health status, functioning, retirement, and pensions.；The baseline survey (Wave 1) was conducted between June 2011 and March 2012, with follow-up surveys occurring biennially.；For this study, the baseline population included participants from Wave 1 who were aged 60 years or older.；From 2011 onward, this longitudinal study tracked participants over a 10-year follow-up period.
核心结论
Participants with cognitive frailty were older and more likely to be female, living in rural areas, and with lower educational levels compared with robust individuals.；In terms of body mass index, individuals with cognitive frailty were more frequently underweight or within the normal range, and less likely to be overweight.；With respect to health conditions, participants with cognitive frailty had a higher prevalence of memory-related disease, arthritis, lung disease, digestive disease, and a history of falls. ‖ 结论：These findings suggest that cognitive frailty may serve as a meaningful composite marker for identifying individuals at high risk of hip fracture.
局限
To our knowledge, this study is among the first to systematically evaluate the long-term predictive value of cognitive frailty for hip fracture risk within a large, community-based cohort, utilizing both cross-sectional and longitudinal analytical frameworks.；A notable cross-sectional study conducted in 2018 [], involving 10,202 older adults, reported that cognitive frailty was significantly associated with fall-related fractures (OR = 1.92, 95% CI: 1.20–3.08), which is consistent with our findings.；First, it utilized a nationally representative sample from CHARLS, enhancing the generalizability and reliability of the findings to the broader older Chinese population.
对本项目的价值
★☆☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。队列：CHARLS、China Health；设计 cross-sectional；最大样本量约 3,870。
全文来源
PMC JATS 全文（正文 26,442 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Cognitive frailty independently predicts hip fracture risk in older Chinese adults: a 10-year prospective analysis.
- 期刊与标识：Aging Clin Exp Res · PMID 42957926 · DOI 10.1007/s40520-026-03464-7
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。