时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Here, we report a secondary analysis of an open-access dataset, conducted in accordance with the Journal of Global Health’s Guidelines for Reporting Analyses of Big Data Repositories Open to the Public (GRABDROP) (Table S1 in the ) [].
方法
We designed an unmatched case-control study based on cognitive impairment among participants aged 65–99 years in the CLHLS 2017–2018 data and their exposure to childhood hunger.；We included 15,874 participants, of whom 12,411 were newly recruited in the 2017–2018 wave, and 3,463 were carried over from previous waves.；We excluded participants who had incomplete responses on the Chinese version of the Mini-Mental State Examination (MMSE), or did not answer the question about whether they ‘often went to bed hungry as a child’ ().；CLHLS was a longitudinal healthy longevity survey among Chinese people aged 65 years and over.
核心结论
The proportion of childhood hunger in the case group was higher than that of the control group (76.62% vs. 69.48%, P < 0.001).；Meanwhile, the constituent ratios of sex (P < 0.001), the decade of birth (P < 0.001), received schooling in childhood (P < 0.001), mother received schooling (P = 0.004), father received schooling (P < 0.001), father had a stable job in participants’ childhood (P = 0.002) and lost mother in childhood (P = 0.033) between case group and control group showed significant difference ().；The crude OR from Model 1 provided a preliminary indication that the association between childhood hunger and later-life cognitive impairment was statistically significant (OR = 1.440; 95% confidence interval (CI) = 1.243–1.667, P < 0.001). ‖ 结论：These findings highlight the importance of children’s living conditions and food security, particularly in economically disadvantaged areas, as improving these factors may correlate with better cognitive outcomes in old age.
局限
It is particularly well suited for assessing such associations in the context of rare diseases or large-scale observational studies [].；To properly interpret these findings, limitations should be acknowledged.；First, we obtained data on childhood hunger from self-report questionnaires.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 9,297。
全文来源
PMC JATS 全文（正文 18,165 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Childhood hunger and cognitive impairment in later life among older adults in China: a nationwide case-control study using target maximum likelihood estimation.
- 期刊与标识：J Glob Health · PMID 42961077 · DOI 10.7189/jogh.16.04317
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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