时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, in recent years, companion animal biobanking has gained increasing attention, and multiple canine brain banks have now been established in Europe and North America (; ; ; ).；However, to the best of our knowledge, the extent to which lipofuscin accumulation in the canine brain is quantitatively associated with canine cognitive dysfunction in larger cohorts, as opposed to simply correlating with chronological age, is an open question.
方法
In early experiments, we performed cannulation of the carotid arteries.；The CT scanner we used was the OmniTom® Elite (NeuroLogica, Danvers, MA), a 16-slice scanner.；This was followed by lead aspartate staining at 60 °C.
核心结论
Of the 55 donors, 27 (49.09 %) had no reported signs of confusion, 27 (49.09 %) had signs ranging from mild to severe, and 1 (1.82 %) had unknown or unreported status.；The gross examination and CT scan modalities were significantly correlated (Spearman rho = 0.66, p = 0.0009, n = 22).；The histological vessel-clearance score was also positively correlated with both the gross score (rho = 0.76, p = 0.001, n = 15) and the CT score (rho = 0.70, p = 0.0017, n = 17), although these comparisons were limited by the smaller number of donors with histological grading. ‖ 结论：McKenzie are employees of Sparks Brain Preservation, a non-profit brain preservation organization.
局限
In our preliminary histologic investigations, we found that hippocampal lipofuscin burden is elevated in dogs with cognitive dysfunction.；However, we note that this histological analysis of lipofuscin is preliminary and exploratory.；We have also presented preliminary analyses of brain aging and ultrastructure that are intended to demonstrate its future research value.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
全文来源
PMC JATS 全文（正文 39,523 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：A canine brain bank for comparative neuroscience and brain aging research.
- 期刊与标识：Free Neuropathol · PMID 42948705 · DOI 10.17879/freeneuropathology-2026-9976
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。