时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Whether p-tau elevation reflects ongoing AD pathology, chronic neuronal injury secondary to long-standing epileptic activity, or a combination of these mechanisms remains uncertain.
方法
Pathological studies have also revealed the presence of amyloid-β (Aβ) pathology (senile plaques) and phosphorylated tau pathology (neurofibrillary tangles) in the patients with refractory epilepsy, suggesting that epilepsy may accelerate AD-related pathological processes (Mackenzie et al., 1996; Tai et al., 2016; Gourmaud et al., 2020).；In the context of recent advances in anti-amyloid antibody therapies, accurate diagnosis of AD based on biomarker assessments within an appropriate clinical context and appropriate selection of patients eligible for disease-modifying treatments have become increasingly important (Ramanan et al., 2023).；Here, we present a case of LOEU that was longitudinally followed for more than 20 years.Case descriptionA right-handed man with 16 years of education presented to our hospital at the age of 60 with episodes of transient forgetfulness.
核心结论
These findings indicate a shared underlying pathophysiology between AD and epilepsy.In recent years, the incidence of new-onset epilepsy in adults aged ≥55 years has increased (Beghi and Giussani, 2018; Hernández-Ronquillo et al., 2018).；Panel B displays longitudinal brain imaging: top row shows serial MRI scans, middle row shows FDG-PET 3D-SSP analysis demonstrating regional metabolic changes, and bottom row shows amyloid PET scans, each column representing different ages from 74 to 84 years.At the age of 70, the patient became aware of mild memory impairment.；As repeated EEG recordings demonstrated sharp waves in the right frontotemporal region, gabapentin was added for seizure management.Despite treatment, cognitive dysfunction continued to worsen, and FIAS escalated to a daily occurrence.
局限
However, detailed longitudinal reports of LOEU with extended follow-up remain scarce.；At age 75, FDG-PET showed no significant change compared with the previous year; however, hypometabolism in the bilateral frontal lobes became evident at age 78.；Text annotations indicate clinical observations such as oral automatism, rhythmic theta, and inability to respond.Levetiracetam was subsequently added; however, seizure control remained poor, leading to readmission at the age of 78 (Ex. 2 in Figure 1 and Table 1).
对本项目的价值
中等价值：属「脑老化与神经退行」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.9/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 29,885 字符，题名指纹 0.94，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：病例报告：一例病因难明难治性晚发性癫痫的脑脊液阿尔茨海默病核心生物标志物纵向评估
- 英文标题：Case Report: Longitudinal evaluation of cerebrospinal fluid Alzheimer's disease core biomarkers in a case of refractory late-onset epilepsy of unknown etiology.
- 期刊与标识：Frontiers in aging neuroscience · PMID 42973984 · DOI 10.3389/fnagi.2026.1807027 · PMC PMC13725761