时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Nevertheless, the relative contribution of individual hydroxyl groups to its neuroprotective effects has not been comprehensively established using systematic structural analogues.；These structural differences may influence biological activity; however, a quantitative relationship between degree of galloylation and neuroprotective efficacy has not been established across a defined series of T. chebula tannins [72] , [73] , [74] .；Further pharmacokinetic and tissue-distribution studies are required to determine the extent to which intact tannins or their metabolites contribute to CNS effects.
方法
2 Literature search and selection strategy 2.1 Databases and search terms This review was conducted as a structured narrative review.；A comprehensive literature search was performed in PubMed, Scopus, Web of Science, Embase, and Google Scholar for articles published between January 2000 and January 2026.；2.3 Evidence categorization and qualitative synthesis Because of substantial heterogeneity in extract composition, dosage, model system, and outcome measures, a qualitative synthesis was performed rather than a meta-analysis.
核心结论
Collectively, these compounds form a polypharmacological profile, which aligns closely with the multifactorial nature of neurodegeneration.；These constituents collectively contribute to the broad pharmacological potential of the plant.；These findings indicate that T. chebula exerts functional neuroprotective effects in vivo in experimental models of Parkinson's disease [51] .
局限
However, these agents modestly slow rather than halt disease progression, are associated with amyloid-related imaging abnormalities (ARIA), and are not widely accessible.；2.4 Limitations of the search strategy No formal risk-of-bias scoring, PRISMA-compliant screening, or quantitative meta-analysis was performed.
对本项目的价值
参考价值：属「线粒体质量控制与氧化应激」方向；脑老化 / 神经退行 / 认知栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.9/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 94,737 字符，题名指纹 0.71，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：诃子作为潜在多靶点神经保护剂：神经退行疾病的转化见解与未来方向
- 英文标题：Black Myrobalan (Terminalia chebula) as a potential multitarget neuroprotective agent: Translational insights and future directions in neurodegenerative diseases.
- 期刊与标识：Biochem Biophys Rep · PMID 42964735 · DOI 10.1016/j.bbrep.2026.102850 · PMC PMC13720627 · EDAT 2026-10-31