时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
Quantifying biological aging and predicting age-related functional decline are increasingly important for reducing the health and socioeconomic burden of population aging. DNA methylation is one of the most extensively studied epigenetic features of aging and underlies epigenetic clocks, promising quantitative biomarkers of biological age. However, the molecular processes driving age-associated DNA methylation changes and the biological signals captured by these clocks remain unclear. A major unresolved issue is the contribution of oxidized 5-methylcytosine (5mC) derivatives to epigenetic remodeling during aging. These derivatives, including 5-hydroxymethylcytosine (5hmC), 5-formylcytosine a…
对本项目的价值
中等价值：属「表观遗传时钟与生物学年龄读数」方向；其他衰老相关栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文不可及原因
标注 OA 但 PDF 下载失败或未通过题名指纹归属校验
原文题录
- 中文题名：超越 5mC：衰老表观基因组中的 5hmC
- 英文标题：Beyond 5mC: 5hmC in the aging epigenome.
- 期刊与标识：Exp Gerontol · PMID 42966422 · DOI 10.1016/j.exger.2026.113374 · EDAT 2026-10-31