时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, such associations still do not establish that urinary organic acid profiling can identify subclinical dysfunction, guide individualized prevention, or monitor metabolic resilience in routine care.；Particular attention is given to whether reported associations, prospective findings, and multi-omics results justify proposed preventive or aging-related applications.
方法
In total, 146 publications underwent full-text review, of which 38 human studies met the inclusion criteria.；Extracted information included report details; study design and population characteristics, including sample size and available age information; sample collection and analysis, including analytical methods and normalization; organic acids and related markers; principal findings, including clinical or functional outcomes and reported effect estimates; confounder adjustment and evaluation procedures; and major limitations.；Evidence was interpreted according to the reported intended use, metabolite coverage, measurement strategy, and supporting evidence for each assay.；The use of additional omics was recorded separately, distinguishing cross-omics statistical analyses or comparisons of omics-derived scores from parallel or pathway-level investigations.
核心结论
In this context, metabolomics investigates metabolic changes associated with genetic predisposition, environmental exposures, nutrition, lifestyle, and host–microbiome interactions , .；Urinary organic acids represent end products and intermediates of multiple biochemical pathways, including carbohydrate metabolism and glycolysis (e.g., lactate, pyruvate), amino acid catabolism (e.g., phenylpyruvate, α-ketoisovalerate), fatty acid β-oxidation and lipid metabolism (e.g., adipate, suberate), and mitochondrial energy metabolism within the tricarboxylic acid (TCA) cycle (e.g., citrate, succinate, fumarate, malate), as well as microbial-derived or host–microbiome co-metabolites (e.g., hippurate, p-hydroxybenzoate) .；These findings have encouraged interest in UOA analysis for preventive health assessment, supported by the non-invasive nature of urine collection and the feasibility of repeated sampling for research . ‖ 结论：This research did not receive any funding or grants from agencies in the public, commercial, or non-profit sectors.
局限
Against this background, a balanced, evidence-based appraisal of UOA analysis is warranted.；A narrative approach was selected to integrate heterogeneous clinical and methodological evidence, discuss current developments, and identify knowledge gaps and future research directions , , .
对本项目的价值
★☆☆☆☆ 方法学进展决定我们能否在有限样本下检出真实效应，属基础设施级收益。设计 cross-sectional、multi-omics。
全文来源
PMC JATS 全文（正文 46,227 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Urinary organic acid analysis in preventive health assessment and healthy-aging research: A state-of-the-art review of evidence and methodological limitations.
- 期刊与标识：Metabol Open · PMID 42959500 · DOI 10.1016/j.metop.2026.100511
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。