时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Cognitive impairment is a symptom or a feature that can be caused by underlying neurological disorders ().；These cognitive impairments result from typical pathological alterations in the brain, such as the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein, which are hallmarks of Alzheimer’s disease (AD).
方法
The minimized systems were subsequently equilibrated under NVT conditions for 100 ps at 300 K using the V-rescale thermostat (τT = 0.1 ps), followed by NPT equilibration for 100 ps at 1 bar using the Parrinello-Rahman barostat (τP = 2.0 ps; compressibility = 4.5 × 10−5 bar-1).；Following this, 100 µL of DMSO was added and incubated for 1 h, followed by gentle shaking to solubilize the crystals.；After 24 h, the cells were washed with lysis buffer, followed by the addition of 500 µL of lysis buffer, and the cells were collected.；To evaluate the antioxidant properties of the test and standard drug, we assessed various antioxidant enzymes.
核心结论
The compound shows no rule violations with one hydrogen bond acceptor, no hydrogen bond donors, and a MolLogP value of 3.27, with a molecular weight of 148.09 g/mol, and suggests favorable oral bioavailability, fully satisfying Lipinski’s criteria (molecular weight <500 g/mol, LogP <5, HBA ≤10, HBD ≤5).；Trans-anethole showed inhibition of CYP1A2 but no inhibition of CYP2C9, CYP2C19, CYP2D6, or CYP3A4, indicating a relatively low risk of significant metabolic interactions.；Additionally, no Brenk structural alerts or PAINS were found, and the synthetic accessibility score of 1.47 denotes ease of synthesis. ‖ 结论：The behavioral, biochemical, and computational data collectively support the potential neuroprotective properties of trans-anethole and provide a basis for further preclinical investigation of its efficacy, molecular mechanism, pharmacokinetic profile, and safety in cognitive impairment.
局限
Thus, these findings should be interpreted as improved performance in memory-related tasks rather than definitive evidence of restored cognition.；However, as the histopathological assessment was qualitative, these findings should be interpreted cautiously and do not independently establish a reduction in cognitive impairment.；Further studies using activated microglial and neural models are needed to confirm the anti-neuroinflammatory and neuroprotective effects of trans-anethole.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
全文来源
PMC JATS 全文（正文 78,310 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Trans-anethole attenuates streptozotocin-induced cognitive dysfunction by modulating oxidative stress and cholinergic activity.
- 期刊与标识：Front Pharmacol · PMID 42964137 · DOI 10.3389/fphar.2026.1954658
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
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