时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
General Practice School of Chongqing Medical University, Chongqing, China. [Received August 14, 2026; Revised October 7, 2026; Accepted October 7, 2026] ABSTRACT: Biological age measures are increasingly derived from target tissues, proximal fluids, and circulating signals, but whether they represent aging of a specific organ remains uncertain.；Future studies should pair target tissue, proximal fluid, and circulating measures with organ pathology or function in the same participants and use repeated measurements to determine whether accessible measures track within-person change.；Pantissue or peripheral blood clocks can capture systemic aging to some extent but cannot establish whether local age-related changes have occurred in a specific organ.
方法
Future studies should pair target tissue, proximal fluid, and circulating measures with organ pathology or function in the same participants and use repeated measurements to determine whether accessible measures track within-person change.；The Biomarkers of Organ-Related Molecular Aging Clocks Aging Consortium subsequently advanced a framework for aging-biomarker terminology, classification, potential clinical use cases, and analytical and clinical validation [20], while later work focused more specifically on predictive validity, cross-cohort comparability, and population-level generalizability [21].；To address this gap, we propose a claim-centered source–resolution–validation (S–R–V) assessment framework.
核心结论
Chronological age prediction was more consistently demonstrated than alignment with organ pathology or function.
局限
Future studies should pair target tissue, proximal fluid, and circulating measures with organ pathology or function in the same participants and use repeated measurements to determine whether accessible measures track within-person change.；However, identifying an organ-associated age deviation does not establish that a model measures aging of the organ itself.；However, prior work has not integrated anatomical signal source, biological resolution, and the maturity of organ attribution evidence within a unified cross-model framework or systematically linked these dimensions to the claims supported by each model.
对本项目的价值
中高价值：属「表观遗传时钟与生物学年龄」方向；表观遗传时钟 / 生物学年龄栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.1/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 22,081 字符，题名指纹 1.0，正文内 DOI 命中，已过题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：组织与器官分子衰老时钟：测量、解读与转化验证
- 英文标题：Tissue- and Organ-Related Molecular Aging Clocks: Measurement, Interpretation, and Translational Validation.
- 期刊与标识：Aging and disease · PMID 42970318 · DOI 10.14336/AD.2026.1010