时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
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摘要（PubMed 原文节选）
OBJECTIVE: Observational studies suggest links between biological aging biomarkers and hearing impairment, but causal inference remains limited. Mendelian Randomization (MR) offers a genetic epidemiological approach to explore potential causal relationships. We used MR to evaluate potential causal associations between various aging biomarkers and five subtypes of hearing impairment. METHODS: We conducted a two-sample MR study using summary data from large-scale, European-ancestry genome-wide association studies. Biological aging biomarkers, including epigenetic clocks, overall and cell-specific telomere length, were used as exposures. Outcomes were age-related hearing impairment and four oth…
对本项目的价值
中等价值：属「表观遗传时钟与生物学年龄读数」方向；方法学 / 生物标志物 / AI 建模栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文不可及原因
标注 OA 但 PDF 下载失败或未通过题名指纹归属校验
原文题录
- 中文题名：年龄相关生物标志物与听力障碍的提示性遗传关联：孟德尔随机化研究
- 英文标题：Suggestive genetic association between age-related biomarkers and hearing impairment: a mendelian randomization study.
- 期刊与标识：Braz J Otorhinolaryngol · PMID 42965988 · DOI 10.1016/j.bjorl.2026.101918 · EDAT 2026-10-31