时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
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摘要（PubMed 原文节选）
The rational engineering of enzymes that coordinate multiple substrates within a confined active site remains a major challenge in biocatalysis. Here, we present a structure-guided dual-cluster engineering strategy that exploits low epistatic coupling among conserved residues to independently tune electronic and geometric active-site feat…
对本项目的价值
参考价值：属「代谢 / 内分泌 / 肝肾老化」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.5/5（★★☆☆☆）
全文不可及原因
无 PMCID 且 Europe PMC / OpenAlex / Unpaywall 未提供可下载 OA 全文
原文题录
- 中文题名：经结构引导重塑烟酰胺单核苷酸腺苷酰转移酶多底物结合口袋以高效合成 NAD+
- 英文标题：Structure-Guided Remodeling of Multi-Substrate Binding Pocket in Nicotinamide Mononucleotide Adenylyltransferase for Efficient NAD+ Synthesis.
- 期刊与标识：Journal of agricultural and food chemistry · PMID 42980414 · DOI 10.1021/acs.jafc.6c08506