时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Fox et al. demonstrated that accelerometer-derived physical activity was associated with slower epigenetic aging in the Rhineland Study [23], while Ammous et al. replicated this finding in the Health and Retirement Study using objectively measured activity [24].；Examining whether smartwatch-derived biomarkers are associated with DunedinPACE may determine whether consumer wearables can support pre-assessment or triage strategies for identifying individuals at higher aging-related risk.In this study, we evaluated whether smartwatch-derived digital biomarkers are associated with the pace of biological aging, quantified using DunedinPACE.；We hypothesized that a smartwatch-derived profile characterized by lower mobility, poorer sleep health, and elevated physiological stress would be associated with higher DunedinPACE, indicating a faster pace of biological aging.
方法
Most DNA methylation-based biomarkers, including DunedinPACE, rely on peripheral blood sampling and molecular assays that may be costly, time-intensive, and inaccessible in many real-world or resource-limited settings [11,16].；Monitoring biological aging in diverse, underserved communities, therefore, requires approaches that transcend the laboratory infrastructure constraints of molecular assays [18-20].Current approaches to assessing aging-related risk are typically based on cross-sectional or episodic measurements, including clinic visits, laboratory testing, and one-time biospecimen collection, which provide only a limited snapshot of an individual’s physiological state [16,17].；Fox et al. demonstrated that accelerometer-derived physical activity was associated with slower epigenetic aging in the Rhineland Study [23], while Ammous et al. replicated this finding in the Health and Retirement Study using objectively measured activity [24].
核心结论
These findings position DunedinPACE as a potentially actionable biomarker; yet it is constrained by the infrastructure required to measure it.Despite these advances, biological aging assessment remains largely confined to blood collection, laboratory processing, and analytic expertise, limiting scalability for population-level screening and repeated monitoring [16,17].；Prior studies have demonstrated that indicators of neighborhood disadvantage, poverty, and structural racism are independently associated with accelerated DNA methylation-based aging, including DunedinPACE, with Black adults consistently showing higher pace-of-aging values compared with White adults, a disparity partly explained by differential exposure to social determinants of health.；Fox et al. demonstrated that accelerometer-derived physical activity was associated with slower epigenetic aging in the Rhineland Study [23], while Ammous et al. replicated this finding in the Health and Retirement Study using objectively measured activity [24].
局限
However, biological aging is a dynamic and continuously evolving process shaped by fluctuations in physical activity, sleep quality, autonomic balance, metabolic stress, and environmental exposures over time [14,18,21].；However, these prior investigations predominantly examined single physiological domains, relied on research-grade or non-wearable measurement tools, or were conducted at single sites, limiting generalizability and ecological validity [14,23].；Given the exploratory nature of this analysis and the number of comparisons performed, FDR correction was not applied; findings should be treated as hypothesis-generating and interpreted with caution pending replication in confirmatory studies.
对本项目的价值
中高价值：属「表观遗传时钟与生物学年龄」方向；表观遗传时钟 / 生物学年龄栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 32,671 字符，题名指纹 0.86，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：智能手表生物标志物提示生物衰老速度
- 英文标题：Smartwatch-Derived Biomarkers Signal Pace of Biological Aging.
- 期刊与标识：Digital health and innovation · PMID 42978780 · DOI 10.3390/dhi1010005 · PMC PMC13727975