时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
We hypothesized that the adipose tissue of the sinus tarsi in patients PCFD represents a neuro-adipose microenvironment characterized by the coexistence of detectable neural elements within the stromal compartment and resident ADSCs with osteogenic differentiation potential, both of which may vary according to age and sex.
方法
The study was approved by the local Ethics Committee of Area Vasta Emilia Centro (Protocol n.；CE-AVEC: 784/2023/Sper/IOR), and written informed consent was obtained from all participants prior to enrollment.；Exclusion criteria comprised the presence of active infections at the time of surgery, pregnancy, contraindications to surgical treatment, and autoimmune diseases.；Cell viability was evaluated after 1 and 3 weeks of culture using the Alamar Blue assay (Thermo Fisher Scientific).
核心结论
In both sexes, patients were evenly distributed by age group, with five individuals younger than 18 years and five aged 18 years or older.；As expected, significant age differences existed between the <18-year and ≥18-year groups in both females (p = 0.0058) and males (p = 0.0012).；Within the ≥18-year group, males were significantly older than females (p = 0.0217). ‖ 结论：Larger, age- and sex-matched studies integrating histological, molecular, imaging, functional, and clinical outcomes are needed to determine whether these biological differences have meaningful implications for the pathophysiology of PCFD and to clarify the potential biological interactions between neural and stromal components.
局限
Furthermore, given the small sample size, these findings should be interpreted as preliminary differences across age-sex groups rather than definitive age- or sex-dependent effects.；This parallel pattern suggests a potential association between neural and stromal cell features within the sinus tarsi microenvironment; however, the present descriptive study does not establish a direct functional or causal relationship between these compartments ().；However, given the exploratory nature of the study and the limited sample size, these findings should be interpreted as preliminary age- and sex-associated patterns rather than definitive differentiation trajectories (–).
对本项目的价值
★☆☆☆☆ 干细胞衰竭与部分重编程决定 rejuvenation 路线的可行边界与安全上限。
全文来源
PMC JATS 全文（正文 34,054 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Sinus tarsi adipose tissue as a neuro-adipose niche in progressive collapsing foot deformity: neural innervation and stem cell properties.
- 期刊与标识：Front Med (Lausanne) · PMID 42952849 · DOI 10.3389/fmed.2026.1925286
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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