时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Nursing care remains important for early complication recognition, patient education, and individualized follow-up, but the present observational study was not designed to test whether specific nursing or procedural strategies improve outcomes.4.5Study limitationsThis study has several limitations.
方法
Although patients may remain asymptomatic for years, symptom onset is associated with a marked deterioration in prognosis, making aortic valve replacement the only treatment that improves survival (1, 4, 5).The prevalence of AS increases markedly with age, affecting approximately 0.2% of adults aged 50–59 years and nearly 10% of those aged 80–89 years (6).；Evidence supporting its use across the surgical-risk spectrum has expanded its indications (9–11), while advances in technology, procedural planning, and implantation techniques have improved safety and clinical outcomes (12).Despite these advances, important sex-related differences persist among patients with AS.；Although TAVI is currently performed with similar frequency in women and men, women continue to experience longer waiting times before intervention, which have been associated with higher 30-day mortality and increased hospitalizations for heart failure (23).Collectively, these findings suggest that sex-related bias may contribute to delays in the diagnosis and treatment of women with AS, as healthcare professionals may underestimate both symptom severity and disease severity in female patients (19).
核心结论
Although TAVI is currently performed with similar frequency in women and men, women continue to experience longer waiting times before intervention, which have been associated with higher 30-day mortality and increased hospitalizations for heart failure (23).Collectively, these findings suggest that sex-related bias may contribute to delays in the diagnosis and treatment of women with AS, as healthcare professionals may underestimate both symptom severity and disease severity in female patients (19).；The peak-gradient variable was not retained in the revised analysis because review of the registry demonstrated non-uniform historical coding across the long study period.With respect to cerebrovascular events, no significant differences were observed in the incidence of stroke (1.8% vs. 1.2%; p = 0.380) or transient ischemic attack (2.0% vs. 2.3%; p = 0.713).；Likewise, Kaplan–Meier and multivariable Cox analyses did not identify sex as an independent predictor of 1-year mortality.These findings are consistent with contemporary evidence.
局限
These observations underscore the importance of incorporating a sex-specific perspective throughout the diagnostic pathway to facilitate earlier recognition, timely referral and equitable access to appropriate treatment.Therefore, further investigation of sex-related differences among patients undergoing TAVI is warranted.；However, the available evidence remains heterogeneous, particularly in the contemporary TAVI era, which is marked by substantial technological advances and increasing operator experience (26).In this context, the present study evaluated sex-related differences in a real-world cohort of patients undergoing TAVI between 2010 and 2023.；However, these analyses largely reflect earlier procedural eras characterized by first-generation devices and greater procedural heterogeneity.
对本项目的价值
中等价值：属「衰弱 / 肌少症功能结局」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 45,864 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：经导管主动脉瓣植入术后临床结局的性别差异：真实世界队列
- 英文标题：Sex differences in clinical outcomes after transcatheter aortic valve implantation: a real-world cohort.
- 期刊与标识：Frontiers in cardiovascular medicine · PMID 42978618 · DOI 10.3389/fcvm.2026.1941651 · PMC PMC13727531