时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
Docking Validation Outcomes To investigate the potential RAPA binding sites on schizophrenia targets, the molecular docking of RAPA was performed with the core targets, including IFNG (PDB ID: 4QGO), IL-10 (PDB ID: 1LQS), IL-4 (PDB ID: 3QB7), IL-2 (PDB ID: 1PY2), IL-1B (PDB ID: 5R88), IL-5 (PDB ID: 4XE1), IL-6 (PDB ID: 5SFK), TNF (PDB ID: 6CU0), IL-17A (PDB ID: 8USR), and IL-1A (PDB ID: 5UC6).；This computational strategy was implemented to determine the anti-schizophrenia mechanisms of RAPA, establishing a theoretical framework for developing novel therapeutics and guiding clinical translation.；The analysis primarily used modeling methods (e.g., network pharmacology and molecular docking) to investigate the role of RAPA in schizophrenia treatment.
方法
Docking Validation Outcomes To investigate the potential RAPA binding sites on schizophrenia targets, the molecular docking of RAPA was performed with the core targets, including IFNG (PDB ID: 4QGO), IL-10 (PDB ID: 1LQS), IL-4 (PDB ID: 3QB7), IL-2 (PDB ID: 1PY2), IL-1B (PDB ID: 5R88), IL-5 (PDB ID: 4XE1), IL-6 (PDB ID: 5SFK), TNF (PDB ID: 6CU0), IL-17A (PDB ID: 8USR), and IL-1A (PDB ID: 5UC6).
核心结论
33 A meta-analysis revealed that individuals with acute or chronic schizophrenia-spectrum disorders exhibited persistently elevated IL-6, IL-10, IL-1B, and TNF levels, and IL-4 and IFNG were significantly reduced in chronic schizophrenia cases compared with healthy controls.
局限
However, this approach is limited by incomplete efficacy across symptom domains and significant adverse effects.；However, mechanistic studies are needed to support the use of RAPA to treat patients with schizophrenia.
对本项目的价值
中等价值：属「营养感知—自噬—蛋白稳态轴」方向；干预策略与临床试验栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 15,057 字符，题名指纹 0.64，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：精神分裂症多靶点治疗：雷帕霉素协调 PI3K-AKT/mTOR 信号与细胞因子网络
- 英文标题：Schizophrenia Multitarget Therapy: Rapamycin Coordinates PI3K-AKT/mTOR Signaling with Cytokine Networks.
- 期刊与标识：Psychiatry Clin Psychopharmacol · PMID 42964522 · DOI 10.5152/pcp.2026.261209 · PMC PMC13720789 · EDAT 2026-10-31