时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
A secondary objective was to explore the potential value of ultrasound-based muscle measurements in identifying sarcopenia.；Therefore, the primary objective of the present study was to determine the prevalence of sarcopenia in patients with axSpA and to evaluate its association with TNFi therapy.；As a secondary, exploratory objective, we further assessed the relationship between ultrasound-derived muscle parameters and sarcopenia in this patient population.
方法
ORIGINAL ARTICLE Archives of Rheumatology 2026 [epub ahead of print] DOI: 10.5152/ArchRheumatol.2026.26292 Sarcopenia in Patients with Axial Spondyloarthritis: Associations with TNF Inhibitor Therapy and Exploratory Ultrasound Findings ABSTRACT Background/Aims: Sarcopenia has gained increasing attention as a potential comorbidity in axial spondyloarthritis (axSpA).；This study aimed to assess the frequency of sarcopenia in patients with axSpA and to investigate its association with tumor necrosis factor inhibitor (TNFi) therapy.；Materials and Methods: This cross-sectional study enrolled 62 adult patients with axSpA who were evaluated during routine rheumatology follow-up.
核心结论
Emerging evidence indicates that Copyright@Author(s) - Available online at archivesofrheumatology.com.；Transverse ultrasound image demonstrating the measurement of subcutaneous adipose tissue thickness (1) and the anteroposterior (2) and transverse (3) diameters of the rectus femoris muscle at the midthigh level with the patient in a seated position.；Transverse ultrasound image demonstrating increased echogenicity of the rectus femoris muscle, consistent with fatty infiltration, accompanied by increased subcutaneous adipose tissue thickness.
局限
Keywords: Axial spondyloarthritis, sarcopenia, tumor necrosis factor inhibitors, ultrasound Introduction Axial spondyloarthritis (axSpA) is a chronic immune-mediated inflammatory condition that primarily affects the axial skeleton and is associated with ongoing pain, stiffness, and gradually worsening functional limitations.；However, the impact of TNFi therapy on muscle health and sarcopenia in axSpA remains insufficiently clarified, with previous studies yielding inconsistent findings.；However, disease duration was significantly longer among patients receiving TNFi therapy (P = .002).
对本项目的价值
中等价值：属「衰弱 / 肌少症功能结局」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 21,479 字符，题名指纹 1.0，正文内 DOI 命中，已过题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：中轴型脊柱关节炎患者的肌少症：与 TNF 抑制剂治疗的关联及超声探索性发现
- 英文标题：Sarcopenia in Patients with Axial Spondyloarthritis: Associations with TNF Inhibitor Therapy and Exploratory Ultrasound Findings.
- 期刊与标识：Archives of rheumatology · PMID 42969474 · DOI 10.5152/ArchRheumatol.2026.26292