时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Further longitudinal and mechanistic studies are needed to clarify whether PPI directly contributes to SO and whether strategies in primary care could mitigate this risk.Elevated triglyceride levels also proved to be a significant risk factor (OR = 1.007 per mg/dL increase, 95% CI: 1.001–1.012, P = .015), as well as history of dyslipidemia (OR = 2.492, 95% CI: 1.024–6.065, P = .044), supporting the premise that lipid accumulation plays a crucial role in the pathogenesis of SO.；In addition, other studies found a higher risk for loss of SMM in females, particularly middle-aged women.2,20 Alternatively, several models reveal the opposite, with findings suggesting that men in the general population have a higher risk of SO.9,17,20 Thus, it remains unclear whether the prevalence of SO is higher in men versus women, suggesting further exploration is needed in this respect.Our study revealed poor agreement between classifications of SO as determined by BMI or BIA.
方法
Text editing was supported by OpenAI’s ChatGPT (GPT-4), while all scientific content and data analysis were conducted and verified by the authors.Patients of both sexes aged ≥30 years who received outpatient medical care between 2022 and 2024 and underwent body composition assessment using bioelectrical impedance analysis (BIA; InBody 570, InBody) were included.；In our center, BIA is routinely performed in all patients during annual check-up visits in our metabolic center.；Additionally, as part of the protocol to be followed at our clinic, it is also measured when patients are identified with metabolic syndrome at the time of their consultation.
核心结论
The model included 463 participants and demonstrated moderate-to-high explanatory power (Nagelkerke R2 = 0.499).；The study revealed significantly different triglyceride levels between the 2 groups.6 Interestingly, our descriptive analysis also showed higher mean HDL levels in the SO group, consistent with previous reports.Although our model did not identify sex as a significant variable, we found sex-based differences between groups in the descriptive analysis, with a higher proportion of females in the SO group (62.5%) when compared to males (37.5%, P = .007).；Although the latest European consensus promotes BMI as a useful screening tool for SO due to its wide utilization in routine clinical practice,5 our findings suggest that it may not be an appropriate measure to routinely evaluate SO.
局限
While our findings suggest a potential adverse effect of PPI use in the pathogenesis of SO, causality cannot be inferred due to the nature of this study; therefore, the results should be interpreted with caution.；In addition, other studies found a higher risk for loss of SMM in females, particularly middle-aged women.2,20 Alternatively, several models reveal the opposite, with findings suggesting that men in the general population have a higher risk of SO.9,17,20 Thus, it remains unclear whether the prevalence of SO is higher in men versus women, suggesting further exploration is needed in this respect.Our study revealed poor agreement between classifications of SO as determined by BMI or BIA.；Additionally, other studies support our findings by also identifying BFP as a more sensitive indicator of BFM distribution.17 Since the diagnostic criteria for SO involves BFP by sex, the previous studies along with our model suggest the use of this parameter as an initial screening tool for SO, when feasible.Undoubtedly, it is essential to acknowledge the limitations of this study.
对本项目的价值
中等价值：属「衰弱 / 肌少症功能结局」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 36,837 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：成人肌少性肥胖的危险因素：生物电阻抗分析病例对照研究
- 英文标题：Risk Factors for Sarcopenic Obesity in Adults: A Case-Control Study Using Bioelectrical Impedance Analysis.
- 期刊与标识：AACE endocrinology and diabetes · PMID 42978981 · DOI 10.1016/j.aed.2026.06.009 · PMC PMC13728249