时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
25 However, while the microcirculation in the retina is sensitive to systemic changes including neuropsychiatric diseases, 26 the associations of these retinal vascular measures with the progression of neuropsychiatric symptomatology in dementia‐free adults remains unknown.；We hypothesized that narrower arteriolar, widening venular caliber, and lower AVR, reflecting greater retinal microvascular alterations, would be associated with MBI.；RESEARCH IN CONTEXT Systematic review : We conducted a literature review using PubMed to examine the neurobiological underpinnings of MBI.
方法
Notably, emerging evidence suggests that vascular risk factor burden, such as diabetes and cardiovascular risk profiles, is associated with MBI and domains, especially in Asian cohorts.；To this end, we examined the association between retinal vascular measures and MBI in a longitudinal Southeast Asian cohort of dementia‐free older adults.；2 METHODS 2.1 Participants This study is part of the ongoing prospective memory‐clinic cohort based in Singapore, where participants were recruited from memory clinics (National University Hospital and St Luke's Hospital) from August 2010 to 2020.
核心结论
Taken together, the findings of this study extend current evidence by highlighting the role of retinal microvascular alterations in vascular processes relevant to neuropsychiatric symptomatology in pre‐dementia individuals.；Interpretation : We showed that reduced CRAE and AVR were associated with incident MBI among dementia‐free older adults, highlighting retinal microvasculature alterations as potential markers of susceptibility to late‐life emergent behavioral disturbances.；Future directions : Future studies should corroborate our findings and integrate additional retinal imaging biomarkers as scalable, non‐invasive approaches to capture domain‐specific behavioral and cognitive changes in larger and more diverse populations.
局限
7 However, existing research has predominantly focused on AD‐related pathology, and further investigation is needed to understand how non‐AD mechanisms, 8 , 9 particularly vascular dysfunction, contribute to the emergence of MBI.；25 However, while the microcirculation in the retina is sensitive to systemic changes including neuropsychiatric diseases, 26 the associations of these retinal vascular measures with the progression of neuropsychiatric symptomatology in dementia‐free adults remains unknown.
对本项目的价值
中等价值：属「脑老化与认知轨迹」方向；皮肤 / 感官 / 口腔老化栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.5/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 39,302 字符，题名指纹 1.00，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：视网膜微血管改变与东南亚无痴呆老年人轻度行为损害相关
- 英文标题：Retinal microvasculature alterations are associated with mild behavioral impairment in Southeast Asian dementia-free older adults.
- 期刊与标识：Alzheimers Dement · PMID 42963327 · DOI 10.1002/alz.71933 · PMC PMC13722608 · EDAT 2026-10-30