时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Adequately powered studies should specifically investigate whether the association between RCII and CV outcomes differs across clinically relevant patient subgroups.In conclusion, present results should be interpreted in light of the limited number of events and the consequent imprecision of the estimates and the observed association should be considered exploratory and hypothesis-generating rather than definitive.
方法
Moreover, RC alone is closely related with a higher risk, faster progression, and adverse events (all-cause mortality or aortic valve re-intervention) in patients with AoS (11–13).；Moreover, CRP is implicated in the progression of AoS and elevated CRP levels, similar to those found in atherosclerosis, are found in patients with degenerative AoS (18).The RCII, which integrates both lipid- and inflammation-driven damage, likely amplifies the overall burden by reflecting vascular injury, glucose-lipid dysregulation, and impaired immune function.；However, the role of the combined RCII parameter in terms of cardiometabolic risk and mortality in AoS elderly patients has not been evaluated still now.
核心结论
Overall, the present results highlight the complexity of the pathophysiological interplay among systemic metabolic dysfunction, frailty, inflammation, and mortality in elderly patients affected by severe degenerative AoS.5.1A possible underlying key mechanistic factorAlthough not directly the focus of the present study, one key feature common to the above inter-relationship observed may be the NLRP3 inflammasome pathway.；In different studies, the combined use of RC and CRP retains a better predictive value than using either indicator alone in the evaluation of CV risk (44, 45).Accordingly, available data suggest that the combination of RC and CRP improved the predictive ability for severity of coronary artery disease (CAD) (46).；Recent data suggest that RCII predicts incident CV disease among patients in the early CV–kidney–metabolic stage (50).
局限
However, the role of the combined RCII parameter in terms of cardiometabolic risk and mortality in AoS elderly patients has not been evaluated still now.；Given the limited number of CV deaths, however, this finding should be regarded as preliminary and hypothesis-generating rather than evidence of an independently established prognostic role.；Nevertheless, it certainly warrants further investigation in future studies.5.5RCII and frailtyInterestingly, we observed an association between RCII and frailty, an important determinant of survival in patients with AoS, that remains challenging to assess due to the decline of multiple physiological systems (19).
对本项目的价值
中等价值：属「衰弱 / 肌少症功能结局」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 32,317 字符，题名指纹 0.88，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：残余胆固醇-炎症指数作为老年重度主动脉瓣狭窄患者心血管代谢风险与心血管死亡率的新型预测因子
- 英文标题：Remnant-cholesterol-inflammatory-index as a novel predictor of cardiometabolic risk and cardiovascular mortality in elderly patients with severe aortic stenosis.
- 期刊与标识：Frontiers in endocrinology · PMID 42973789 · DOI 10.3389/fendo.2026.1894558 · PMC PMC13724505