时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Therefore, we tested whether premature epigenetic aging predicts deviations from normative brain development and cognition in young adulthood.；Specifically, we aim to test whether the relationship between premature epigenetic aging and worse cognitive outcomes in young adulthood might be mediated by deviations from normative development of brain structure.；Further, we aim to determine whether these relationships between premature epigenetic aging, deviations from normative brain development, and cognitive outcomes might be sex-specific.
方法
Transl Psychiatry (2026). https://doi.org/10.1038/ s41398-026-04337-3 We are providing an unedited version of this manuscript to give early access to its findings.；Therefore, we tested whether premature epigenetic aging predicts deviations from normative brain development and cognition in young adulthood.；We followed 254 young adults from the ELSPAC prenatal birth cohort.
核心结论
Given the increasing percentage of adults over 65, there is also a higher prevalence of dementia as well as other health-related issues (3, 4, 5, 6) ES S A growing body of evidence indicates that many age-related diseases originate in young adulthood or even early life (7, 8, 9), underscoring the need for a lifespan perspective on aging-related pathology.；Horvath also demonstrated that the heritability of age acceleration is 100% in newborns, but only 39% in older subjects, suggesting non-genetic factors become more relevant in later life (11).；Previous structural neuroimaging research has consistently demonstrated that individual differences in cognitive performance and intelligence correlate with variations in regional brain macrostructure, including cortical thickness and subcortical volumes (21, 22, 23).
局限
However, the underlying brain structure reflecting the altered brain dynamics and cognitive performance is not well understood.
对本项目的价值
中高价值：属「表观遗传时钟与生物学年龄」方向；表观遗传时钟 / 生物学年龄栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
出版商/仓储 OA PDF（正文 12,766 字符，题名指纹 1.0，正文内 DOI 命中，已过题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：成年早期的过早表观遗传衰老、规范脑发育偏离与认知表现
- 英文标题：Premature epigenetic aging, deviations from normative brain development, and cognitive performance in young adulthood.
- 期刊与标识：Translational psychiatry · PMID 42977740 · DOI 10.1038/s41398-026-04337-3