时间标签：数据日期 2026-10-28 · 生成时间 2026-10-31 05:30（Asia/Shanghai）｜ 档位：观察哨47 ｜ 窗口 T-3 ｜ 上游评级 C
这项研究想回答什么
能否用标准化问卷采集 iRBD 人群的环境暴露史？
方法与数据
自报式多域问卷（药物/溶剂/烟尘/重金属 + 居住与职业 + 生活方式），按"确诊/很可能/可能/不确定或不可能"分级，并记频率、生命阶段与防护用具使用。
核心结论
以下所有数字均可在官方 abstract 原文（见第 7 节）中逐字核对；上游未给出的定量一律写「未给出」，不估算、不换算。
- 一句话贡献：83 名多导睡眠图确诊 iRBD 者完成 SEEQ，81 人（97.6%）完成全部四个直接暴露域；农药、溶剂/工业化学品、焊接烟尘、重金属的确诊/很可能暴露率分别为 38.6%、43.4%、21.0%、34.1%。
局限与未核验项
样本仅 83 例，暴露全为自我报告且无客观暴露验证；横断面显示暴露负荷与自主神经症状相关，但未与纵向临床恶化相关。
补全文时优先核：问卷的信效度检验、与客观暴露（职业记录/生物监测）的一致性、生命阶段权重的设计依据。
⚠️ 本页为摘要级解读：未取得 PDF 全文，上述所有结论均未核至 Results/Methods；效应量、样本量、统计方法与多重比较校正在多数条目中仍未知。
对本领域的价值
帕金森前驱期环境暴露的标准化采集工具，可外推到其他神经退行队列的环境暴露分层；与衰老本身关联偏间接，属长尾命中。
编辑研判
工具型条目，可外推到其他神经退行队列的环境暴露分层：83 名 PSG 确诊 iRBD 者完成 SEEQ，81 人（97.6%）完成四个直接暴露域，农药 38.6%、溶剂/工业化学品 43.4%、焊接烟尘 21.0%、重金属 34.1%（确诊/很可能）。分级方式（确诊/很可能/可能/不确定）与频率、生命阶段、防护用具的三维记录值得照搬。限制明确：仅 83 例、全为自我报告无客观验证，且横断面下暴露负荷只与自主神经症状相关、未与纵向临床恶化相关。与衰老本身关联偏间接。
官方摘要原文（逐字，供回溯）
展开 api.biorxiv.org / api.medrxiv.org 返回的 abstract 原文
Objective: To describe development of the Portland Suspected Environmental Exposures Questionnaire (SEEQ) and its initial application for environmental exposome profiling in isolated REM sleep behavior disorder (iRBD). Background: Environmental exposures may contribute to Parkinson disease and related synucleinopathies, yet existing instruments variably capture specific agents, co-exposures, exposure uncertainty, timing, and mitigating factors. Methods: SEEQ was iteratively developed to assess pesticides, solvents/industrial chemicals, welding fumes, heavy metals, residential and occupational exposures, and relevant lifestyle factors. Direct exposures were classified as definite, probable, possible, or uncertain/unlikely, with additional assessment of frequency/duration, life stage, and protective-equipment use. SEEQ was administered to participants with polysomnography-confirmed iRBD. Exposure prevalence, co-exposure patterns, and exploratory associations with clinical phenotypes and longitudinal progression were examined. Results: Eighty-three participants completed SEEQ; 81 (97.6%) completed all four direct exposure domains. Definite/probable exposure was reported for pesticides in 38.6%, solvents/industrial chemicals in 43.4%, welding fumes in 21.0%, and heavy metals in 34.1%. Among complete responders, 60.5% reported [≥]1 and 42.0% [≥]2 direct exposure domains. Forty-five participants identified [≥]1 named agent or mixture. Greater exposure burden was cross-sectionally associated most consistently with greater autonomic symptom burden, but was not associated with longitudinal clinical worsening. Conclusion: SEEQ provides a practical, multidomain framework for structured environmental exposome profiling in prodromal synucleinopathy. Larger studies with external exposure validation and longitudinal follow-up are needed.
本文为预印本，未经同行评审，结论可能在正式发表时变更。生成任务 12819187（预印本全文级解读）· 上游 12784209（预印本速递）。
C 级证据分级：C 级（预印本，未经同行评审；本页为摘要级，未核至全文）
本文为预印本，未经同行评审；且本页为「摘要级」——未取得 PDF 全文（源站封锁），全部结论只依据官方 API 摘要原文。效应量、样本量、统计方法与多重比较校正在多数条目中仍未知，摘要未给出之处一律写「未给出」/「待补全文」，未做任何数值推算补全。
关于本文的文献来源：本站依据元层《预印本全文级解读_2026-10-31》（上游《预印本速递_2026-10-31》）撰写，附官方 abstract 原文供逐字回溯。