时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Alzheimer’s disease and related dementias (ADRDs) represent a major and growing public health challenge.；However, IL-6 may also be a downstream marker of an already active neurodegenerative process; for example, higher cerebrospinal-fluid IL-6 relates to higher neurofilament light, a marker of axonal injury, in early Alzheimer’s disease ().；Determining whether IL-6 levels confer comparable risk across ethno-racial groups may help identify generalizable dementia biomarkers suitable as intervention endpoints.
方法
The analytic sample included HABS-HD participants with complete data on cognitive diagnosis, Geriatric Depression Scale (GDS; ) score, plasma IL-6, age, education, sex, and race/ethnicity.；Cognitive impairment was operationalized as a binary diagnostic outcome, with participants classified as cognitively unimpaired or cognitively impaired.；The complete-case sample included participants across three racial/ethnic groups: 277 Black participants, 947 Hispanic participants, and 963 White participants.；For the Black/White matched analyses, a 1:1 matched sample was created by matching White participants to Black participants.
核心结论
Higher log-transformed plasma IL-6 was significantly associated with greater odds of cognitive impairment after adjustment for age, education, sex, ethnoracial group, GDS total score, and APOE ε4 carrier status (OR = 1.31, 95% CI [1.12, 1.53], p = 0.001).；Higher GDS scores were also independently associated with cognitive impairment.；Each 1-point increase in GDS total score was associated with approximately 6% greater odds of cognitive impairment after adjustment for IL-6 and the remaining covariates (OR = 1.06, 95% CI [1.04, 1.08], p < 0.001). ‖ 结论：This has important implications for equitable biomarker development and precision prevention strategies: interventions targeting IL-6 (e.g., lifestyle modification, anti-inflammatory therapies, or depression management) could benefit diverse populations without requiring race/ethnicity-specific tailoring.
局限
This finding persisted in the propensity score-matched subsamples, where we minimized demographic confounding through exact matching on sex and cognitive status.；However, the Hispanic-specific estimate was weaker and nonsignificant, which may reflect heterogeneity within the Hispanic sample or other demographic, vascular, metabolic, or sociocultural factors.；Future studies incorporating cardiometabolic risk, cerebrovascular imaging, social determinants of health, and longitudinal inflammatory measures will be needed to evaluate these potential pathways.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 2,187。
全文来源
PMC JATS 全文（正文 33,754 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Plasma IL-6 as a shared inflammatory marker of cognitive impairment across racially and ethnically diverse older adults: matched analyses from the HABS-HD study.
- 期刊与标识：Front Dement · PMID 42952734 · DOI 10.3389/frdem.2026.1930196
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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