时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Biomarker-rich dietary trials can test whether these effects translate to emotional and fatigue-related outcomes during the menopausal transition.Polyphenols are similarly microbiota-active.；Objective sleep architecture is rarely measured, highlighting the value of perimenopause-specific trials that combine actigraphy or polysomnography with emotional outcomes.；Prospective studies initiated at specific STRAW+10 stages can test whether nutritional response varies across this window.Future trials should integrate STRAW+10 staging (206), symptom-cluster phenotyping (3, 4), dietary-context assessment and microbiome/metabotype profiling (78, 81, 100, 101, 156), and validated outcome instruments for sleep, mood, cognition, vasomotor symptoms, fatigue and quality of life.
方法
Dietary studies capture combined exposures but rarely isolate emotional outcomes in well-staged perimenopausal cohorts, whereas product trials test defined preparations but are generally small and short.；Longitudinal cohorts consistently identify the menopausal transition as a period of increased vulnerability to depressive symptoms and major depression (1, 2).；Clinical evidence concerns exogenous melatonin: one meta-analysis of randomized trials in menopausal women found no significant benefit for sleep quality, anxiety, or depression (72), whereas a later meta-analysis focused on postmenopausal women reported reductions in depression and anxiety scores (73).
核心结论
In longitudinal human data, high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) follow distinct trajectories across the final menstrual period (57), while multimodal neuroimaging demonstrates stage-related changes in brain structure and glucose metabolism during reproductive aging (58).；Together, these findings connect endocrine aging with redox, immune, and bioenergetic remodeling.Acting as downstream interfaces of the immune-redox-neuroplasticity axis, the endocrine and neuroimmune disturbances outlined above converge on monoaminergic neurotransmitter systems that shape mood regulation, sleep architecture, thermoregulation, and cognitive function (59).；These findings place BDNF-related signaling at the intersection of estrogen variability, HPA activation, and neuroinflammation (74–76), while circulating BDNF remains a clinical correlate rather than a direct measure of central tropomyosin receptor kinase B (TrkB) activity (Figure 2, panel 4).3.3Gut-brain-metabolic axisThe gut microbiota contributes to neuroendocrine and immune regulation, and its diversity, composition, and hormone-related functions change across the menopausal transition and postmenopause (78, 79).
局限
Equol-producer status therefore warrants consideration in future perimenopause trials as a candidate effect modifier rather than a peripheral methodological detail.；Recording matrix, formulation, dose, and background diet allows clinical findings to be assigned to the exposure actually tested.Where feasible, future studies should incorporate exposure and target-engagement markers, including equol status, urolithin metabotype, enterolignan production and circulating polyphenol metabolites (99, 101–103).
对本项目的价值
中等价值：属「代谢 / 内分泌 / 肝肾老化」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.7/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 64,379 字符，题名指纹 0.82，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：植物来源营养与围绝经期情绪健康：现有证据与研究优先级
- 英文标题：Plant-derived nutrition and perimenopausal emotional health: current evidence and research priorities.
- 期刊与标识：Frontiers in nutrition · PMID 42973544 · DOI 10.3389/fnut.2026.1961915 · PMC PMC13724517