时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
The extraction sheet was developed in Microsoft Excel 365 and included all prespecified fields required to address the study objectives.Data extraction was performed independently and in parallel by two reviewers (MH and MJ) using a piloted, standardized extraction form.；Diagnostic and prediction-model results were therefore summarized descriptively, with emphasis on whether findings were externally validated, internally cross-validated only, or exploratory [10].；The plot was used to summarize whether key methodological and analytical features were clearly reported/performed, partially reported/performed, or not reported/absent across the included studies.ResultsStudy selectionThe database search identified 9,354 records, including 5533 from PubMed, 2639 from Scopus, and 1182 from Embase.
方法
This creates an important translational gap: patients with similar clinical diagnoses may have distinct biological profiles, illness trajectories, and treatment responses.；Many findings are study-specific, platform-dependent, and limited by small samples, variable diagnostic definitions, medication exposure, cell-composition effects, and incomplete external validation.；To support this translational focus, we additionally assessed blood source, platform heterogeneity, validation status, prediction-model limitations, and certainty of evidence using modified QUADOMICS, PROBAST, and modified GRADE frameworks.MethodsStudy design and reportingThis systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) [7] guidance.
核心结论
Current evidence indicates that MDD cannot be explained by a single biological pathway; instead, it reflects interacting genetic, environmental, psychological, inflammatory, neuroendocrine, metabolic, and neurobiological processes [1].；The reported biological domains included immune-cell signalling, mitochondrial RNA-processing, and circadian regulation; however, because this was a candidate-gene case-control design without external validation, these findings should be interpreted as exploratory transcriptomic signals rather than clinically established diagnostic markers [41].；Overall, recurrent or candidate transcriptomic signals included MX1, OAS1, IFIT3, IRF1, MDGA1, LC3A/MAP1LC3A, BICD2, PECR, CD19, MTPAP, PER3, and NF-κB/type I interferon-related pathways; however, pathway-level convergence remained stronger than single-transcript reproducibility.Blood DNA methylation signatures in MDDDNA methylation was one of the most frequently represented and consistently reported biomarker domains.
局限
However, evidence of brain-blood molecular convergence does not by itself establish clinical utility.；To support this translational focus, we additionally assessed blood source, platform heterogeneity, validation status, prediction-model limitations, and certainty of evidence using modified QUADOMICS, PROBAST, and modified GRADE frameworks.MethodsStudy design and reportingThis systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) [7] guidance.；Trial registries and grey literature sources, including conference abstracts, were not systematically searched and this was considered a limitation of the review.Eligibility criteriaStudies were eligible if they were original human studies evaluating blood-derived or peripheral molecular biomarkers in MDD or clinically defined depressive phenotypes with extractable MDD/depression-relevant data.
对本项目的价值
中高价值：属「线粒体质量控制与氧化应激」方向；线粒体功能与氧化应激栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.3/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 76,743 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：重性抑郁障碍的外周分子签名：血液生物标志物用于诊断、分层与疗效应答的系统综述
- 英文标题：Peripheral molecular signatures of major depressive disorder: a systematic review of blood-derived biomarkers for diagnosis, stratification, and treatment response.
- 期刊与标识：BMC psychiatry · PMID 42968091 · DOI 10.1186/s12888-026-08450-x · PMC PMC13726245