时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Consequently, addressing bone defects has become a significant and pressing challenge in clinical practice.；Specifically, autologous bone grafting remains the “gold standard” for bone defects but is limited by donor‑site morbidity and finite harvest volume [].；However, these two research areas have largely been treated independently.
方法
The inclusion criteria comprised: (1) peer-reviewed original research papers; (2) studies investigating biomaterials for bone defect repair; and (3) research involving relevant in vitro or in vivo biological evaluations.；The exclusion criteria comprised: (1) conference abstracts, book chapters, unpublished papers or preprints; (2) studies focusing on non-biomedical engineering materials or purely theoretical/computational models without biological validation; and (3) articles with insufficient methodological clarity or lacking appropriate control groups.；The underlying mechanism was explored via high-throughput sequencing biotechnology.
核心结论
Consequently, addressing bone defects has become a significant and pressing challenge in clinical practice.；Anchored by the cell niche, the coordinated interplay of multiple cellular microenvironments collectively regulates the biological behaviours and fate decisions underlying bone defect repair [, ].；Previous reviews have extensively discussed either surface topography or electrical stimulation as individual strategies for enhancing bone regeneration. ‖ 结论：These emerging strategies highlight the critical role of interfacial phenomena in orchestrating complex cellular behaviours during bone regeneration.
局限
To overcome the limitations of current treatment strategies, a diverse array of bone repair materials has been developed to meet pressing clinical needs.；These preliminary findings underscore topography-driven mechanotransduction as a pivotal factor in bone-regenerative biomaterial design [].
对本项目的价值
★☆☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。
全文来源
PMC JATS 全文（正文 93,275 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration.
- 期刊与标识：J Nanobiotechnology · PMID 42958509 · DOI 10.1186/s12951-026-04852-x
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