时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Cognitive decline and frailty progression are growing global health challenges amid rapid population aging [].；Taken together, existing evidence suggests that both online and offline social activity engagement may contribute to cognitive and physical health; however, how these two forms of engagement jointly develop over time remains less well understood.；First, although longitudinal studies have examined trajectories of social activity and have considered Internet use together with social participation among middle-aged and older adults [, ], little is known about the joint longitudinal trajectories of online and offline social activity engagement.
方法
This longitudinal cohort study used data from CHARLS, a nationally representative survey primarily targeting Chinese adults aged 45 years and older.；CHARLS enrolled more than 17,000 participants across 28 provinces at baseline in 2011–2012, with follow-up assessments conducted every 2 years through face-to-face computer-assisted interviews.；All procedures performed in this study involving human participants were in accordance with the ethical standards of the Peking University Institutional Review Board (IRB00001052-11015) and with the 1964 Helsinki declaration and its amendments or comparable ethical standards.；Of 17,708 baseline participants, 777 were excluded due to age <45 years or missing age information, and 2,591 were further excluded due to missing baseline online and offline social activity data or lack of follow-up assessments.
核心结论
Global cognition declined significantly over time (coefficient = −0.055, 95% CI [-0.061, −0.049], p < 0.001).；Compared with the Persistently Low Social Activity Engagement Group, the Offline Social Activity Dominant Group showed a modestly slower decline in global cognition (G2 × time: coefficient = 0.010, 95% CI [0.002, 0.018], p = 0.011).；The Online Social Activity Increasing Group showed a stronger attenuation of cognitive decline (G3 × time: coefficient = 0.044, 95% CI [0.029, 0.060], p < 0.001). ‖ 结论：Given the relatively small and sociodemographically distinct G3 subgroup, larger studies with more detailed measures of digital engagement are needed to validate these findings.
局限
However, these findings should be interpreted as longitudinal associations rather than causal effects.；Because some subgroup-specific estimates, particularly for G3, had wider confidence intervals, these findings should be interpreted cautiously and as hypothesis-generating rather than confirmatory.；Several limitations should be acknowledged.
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。队列：CHARLS；最大样本量约 14,340。
全文来源
PMC JATS 全文（正文 28,466 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Joint trajectories of online and offline social activity, cognitive decline, and frailty progression among middle-aged and older adults in China.
- 期刊与标识：Int J Public Health · PMID 42952780 · DOI 10.3389/ijph.2026.1610116
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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