时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Compounding this challenge, advanced optic disk cupping has been recognized as a potential cause for acquired disk pit formation and associated disk-originating fluid, further blurring diagnostic boundaries in elderly patients with multiple concurrent ocular diseases [, , ].
方法
She had received 8 intravitreal bevacizumab injections, followed by 3 intravitreal aflibercept 2 mg injections, with the last aflibercept injection administered approximately 3 months prior to presentation.；[] reported a broad range of misdiagnoses across their occult optic pit cohort, including central serous chorioretinopathy, retinal vein occlusion, macular edema, and AMD [, ].；[] similarly found glaucoma in 64% (7 of 11 eyes) of their cohort.
核心结论
ODPs arise from incomplete closure of the embryonic fissure during ocular development and are considered part of a spectrum of cavitary optic nerve head anomalies that also includes optic nerve coloboma and morning glory disk anomaly, all of which share the histopathological feature of herniation of dysplastic retinal tissue through a defect in or around a disrupted lamina cribrosa [, ].；This entity has been described under several terminologies: occult optic pit maculopathy (OOPM), when a pit can be demonstrated on careful OCT or near infrared imaging [], no Optic Pit Retinoschisis (NOPIR), which can include cases with no identifiable structural pit [], and ODP-like maculopathy, as a broader term encompassing both presentations [].；Common to all these presentations is the critical diagnostic feature of absent fluorescein leakage from the macula, which distinguishes them from neovascular or inflammatory causes of macular fluid. ‖ 结论：These observations collectively support an initial strategy of observation for patients with disk-originating maculopathy who maintain good visual acuity and lack progressive foveal involvement, reserving surgical intervention for optic disk maculopathy, such as pars plana vitrectomy, for cases with significant and progressive visual loss [, , , ].
局限
Conventional macular OCT protocols frequently do not adequately sample the optic nerve head or may not demonstrate that nasal macular fluid is extending from the optic disk margin.
对本项目的价值
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全文来源
PMC JATS 全文（正文 14,974 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Occult Optic Disk Pit Maculopathy Masquerading as Exudative Age-Related Macular Degeneration in an Elderly Patient: A Case Report.
- 期刊与标识：Case Rep Ophthalmol · PMID 42953591 · DOI 10.1159/cop/acaag013
A 级证据分级：A 级（同行评议人体研究）
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