时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
However, the broader traditional perception of IGE as a benign disorder with limited long-term clinical impact has been challenged by accumulating evidence that individuals with IGE may experience persistent cognitive impairment (), psychiatric comorbidities (), and, in a substantial subset, inadequate seizure control or resistance to antiseizure medications ().；However, the direction and location of these findings have varied substantially across studies, with some reporting GM increases, others reporting decreases (), and several reporting no significant differences ().；In this context, functional connectivity network mapping (FCNM) provides a framework for testing whether spatially heterogeneous brain abnormalities are connected to a common functional network.
方法
Following the PRISMA guidelines, we conducted a comprehensive systematic search of the PubMed, Embase, and Web of Science databases to identify VBM studies on GM alterations in IGE, published up to 5 May 2026.；Studies were included according to the following criteria: (a) published in an English-language peer-reviewed journal as an original article; (b) investigated VBM-based differences in GM density or volume between IGE patients and HCs; and (c) reported whole-brain VBM findings with three-dimensional peak coordinates in Talairach or Montreal Neurological Institute (MNI) space.；Exclusion criteria were as follows: (a) non-original studies (e.g., review, meta-analysis, meeting abstract); (b) no coordinate system reported; (c) only reported regions of interest (ROI) results; (d) all reported coordinates outside the GM mask; (e) studies reporting results based on small-volume correction;
核心结论
After a systematic literature search and screening (), the 18 included studies yielded 18 independent contrasts and 111coordinates, including coordinates reflecting both decreased and increased GM.；Using the HCP normative connectome, FCNM revealed that anatomically heterogeneous GM alterations reported in IGE were associated with a common observed distributed normative connectivity pattern.；The principal nodes of this network were located in the bilateral middle temporal gyri (MTG), bilateral thalami, left superior frontal gyrus (SFG), and right putamen (voxel-wise FDR-corrected p < 0.05; network probability threshold ≥ 60%) (). ‖ 结论：However, because no coordinate-based null-model or permutation analysis was performed, these findings do not establish convergence beyond chance or disease-specific subcortical involvement.
局限
Importantly, because connectivity was derived from healthy participants, the identified network should be interpreted as the normative functional network connected to reported IGE-related GM alteration sites, rather than as direct evidence of abnormal functional connectivity in patients.；Studies using dynamic causal modeling and Granger causality analysis have additionally reported directional abnormalities in effective connectivity within the DMN (, ).；The thalamus is robustly engaged across the three principal seizure types associated with impaired consciousness—complex partial, generalized tonic–clonic, and absence seizures—and exhibits combined structural and functional connectivity abno
对本项目的价值
★☆☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 1,492。
全文来源
PMC JATS 全文（正文 37,363 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Normative functional network localization of gray matter alterations in idiopathic generalized epilepsy.
- 期刊与标识：Front Neurol · PMID 42959045 · DOI 10.3389/fneur.2026.1957963
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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