时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
However, the precise developmental window during which MNP exposure exerts its intergenerational effects, whether via direct interference with epigenetic reprogramming in primordial germ cells or via oxidative damage to mature sperm chromatin, remains to be determined and warrants future investigation.6Intervention measuresCurrent research on male reproductive toxicity induced by MNPs remains at an early stage, and no clinically validated targeted therapeutic interventions are currently available.；It is important to emphasize that all strategies described above, whether environmental, pharmacological, or behavioral, remain at the experimental or theoretical level.；Direct clinical evidence validating the reproductive hazards of MNPs in humans and their combined toxicity mechanisms remains unclear.
方法
We included studies addressing environmental exposure characterization, human biomonitoring, in vivo mammalian toxicopathology, in vitro cellular and molecular mechanisms, intergenerational toxicity, and therapeutic or preventive strategies.；Pharmacological treatment efficacy varies considerably among individual patients, and long-term medication intervention commonly reduces patient treatment compliance.；Refractory male infertility imposes severe psychological pressure on male patients, undermines family happiness and harmony, and further poses a serious threat to public health.
核心结论
Given that MPs can further fragment into NPs in the internal environment, these findings have raised public concerns regarding the potential reproductive toxicity of MPs and their smaller derivatives.；Studies lacking essential physicochemical particle characterization, presenting duplicate datasets, or demonstrating inadequate methodological rigor were systematically excluded to ensure data reliability.；Meta-analysis evidence reveals that global male sperm counts have exhibited a significant downward trend from 1973 to 2018, with a more drastic decline observed after 2000 (11, 12).
局限
Once absorbed into the systemic circulation, these particles may accumulate in certain tissues; however, the potential for subsequent harm to human organs remains incompletely understood and varies considerably with particle type, size, dose, exposure route, and the experimental model or species examined.；It is noteworthy, however, that the experimental conditions employed in the reviewed studies often differ substantially from realistic human exposure settings.2Male infertility2.1The epidemiological status of male infertilityMale infertility represents a prevalent disease in andrology and reproductive clinics.；Meanwhile, external risk factors such as smoking, alcohol consumption, and sleep deprivation can also induce damage to the male reproductive system.2.2Diagnostic and treatment bottlenecksCurrent diagnostic and therapeutic strategies for male infertility have inherent limitations in clinical practice.
对本项目的价值
中高价值：属「营养感知—自噬—蛋白稳态轴」方向；mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.1/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 63,928 字符，题名指纹 0.82，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：微纳塑料暴露：雄性生殖毒性、机制与研究展望
- 英文标题：Micro- and nanoplastic exposure: male reproductive toxicity, underlying mechanisms, and research prospects.
- 期刊与标识：Frontiers in endocrinology · PMID 42974292 · DOI 10.3389/fendo.2026.1940055 · PMC PMC13725550