时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
（原文未给出可直接抽取的对应表述）
方法
Therefore, resveratrol has a prominent functional role in its antileukemic activity.90Most evidence regarding cell lines is in vitro, and clinical evidence for the efficacy of resveratrol in leukemia remains limited.Given the profound heterogeneity among hematologic malignancies, the biological consequences of resveratrol exposure diverge substantially across acute versus chronic, and myeloid versus lymphoid lineages.；Survival outcomes in young adults have improved with the adoption of pediatric-inspired treatment regimens.114 However, elderly patients often exhibit lower overall survival and remission rates, largely because they are less tolerant of intensive chemotherapy.；Poor clinical outcomes are also observed in patients with relapsed ALL or treatment-resistant disease, regardless of age.
核心结论
Carcinogenesis involves complex molecular and cellular alterations and typically progresses through distinct stages known as initiation, promotion, and progression.2 Findings obtained from studies using leukemia cell lines have therefore provided valuable perspectives on emerging drug targets and therapeutic approaches.15Several studies have demonstrated that resveratrol can enhance the sensitivity of resistant malignant cells to chemotherapeutic drugs by modulating one or more mechanisms associated with chemoresistance.；Therefore, careful consideration of the optimal dosage and duration of resveratrol administration is essential.43Anti-Inflammatory Effect of ResveratrolAnother important property of resveratrol demonstrated in numerous studies is its potent anti-inflammatory activity.；These findings indicate DNA fragmentation and loss of membrane phospholipid asymmetry.
局限
However, despite advances in cancer therapy, the emergence of acquired resistance to chemotherapy drugs remains a major challenge.；However, in certain experimental contexts, resveratrol has also been presented to exert chemoprotective effects in normal cells.4Earlier reviews on resveratrol’s anticancer properties mostly covered solid tumors or gave broad overviews of polyphenols in hematologic cancers, lacking detailed, mechanism-focused comparisons across leukemia subtypes.；To overcome limitations associated with its low bioavailability, various formulation strategies have been investigated.
对本项目的价值
中高价值：属「营养感知—自噬—蛋白稳态轴」方向；mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.1/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 58,305 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：白藜芦醇的机制与治疗潜力：聚焦白血病
- 英文标题：Mechanisms and Therapeutic Potential of Resveratrol: Focus on its Effect on Leukemia.
- 期刊与标识：OncoTargets and therapy · PMID 42974114 · DOI 10.2147/OTT.S624444 · PMC PMC13725090