时间标签：数据日期 2026-11-03 · 生成时间 2026-11-03 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31 – 2026/11/03 ｜ 情报发生日期 2026-11-03
研究问题
We therefore constructed a composite measure—the HALP–Sarcopenia Combined Index (HS-index)—and investigated whether it is associated with lymph-node metastasis and recurrence in women undergoing primary surgery for endometrial carcinoma.；Molecular classification was not available, so we were unable to determine whether the association of the HS-index with outcomes varies by molecular subtype.；Finally, the absence of external validation and the modest sample size limit the generalisability of the findings, which should be considered hypothesis-generating.
方法
Separately, sarcopenia, defined by low skeletal-muscle mass on cross-sectional imaging, is associated with impaired treatment tolerance, postoperative morbidity and worse oncological outcomes across gynaecological cancers.；Methods Study Design and Population We conducted a single-centre retrospective cohort study of consecutive women with histologically confirmed endometrial carcinoma who underwent primary surgery.；Flowchart sequence of screening, exclusions, analytic cohort, HS-index calculation and two endpoints.
核心结论
Our findings sit alongside, and help reconcile, a divided literature.；22 Our results add to this body of work by showing that combining the haematological–nutritional axis (HALP) with the body-composition axis (SMI) yields a significant composite signal even when neither axis reaches significance alone.
局限
Because standardisation used cohort-specific means and standard deviations, these reference values would need to be re-estimated before the index can be applied in an independent population; this is acknowledged as a limitation.；The sole exception was the non-endometrioid subgroup (n = 9, 5 events), which showed a point estimate in the opposite direction (OR 1.94, 0.26–14.29); however, this subgroup was too small to permit meaningful interpretation.
对本项目的价值
参考价值：属「衰弱 / 肌少症功能结局」方向；肌肉骨骼 / 衰弱 / 肌少症栏目可用作本项目文献库与综述素材。 ｜ 价值分 1.9/5（★★☆☆☆）
全文来源
PubMed PMC JATS（正文 32,688 字符，题名指纹 0.92，已过 DOI 逐字 + 题名指纹 + 正文长度三重归属校验）
原文题录
- 中文题名：整合炎症、营养与骨骼肌的复合评分用于淋巴结转移术前风险分层
- 英文标题：Integrating Systemic Inflammation, Nutrition and Skeletal Muscle into a Composite Score (the HALP-Sarcopenia Combined Index) for Preoperative Risk Stratification of Lymph-Node Metastasis and Recurrence in Endometrial Carcinoma: A Single-Centre Retrospective Study.
- 期刊与标识：Int J Womens Health · PMID 42967187 · DOI 10.2147/IJWH.S647101 · PMC PMC13723243 · EDAT 2026-11-01