时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
In a national matched cohort study in Denmark, time-to-event analyses described binary and dose-response associations between hospitalisation and subsequent fracture events.
方法
In a national matched cohort study in Denmark, time-to-event analyses described binary and dose-response associations between hospitalisation and subsequent fracture events.；This national matched cohort study was performed using Danish registry data available for individuals aged >45 years.
核心结论
Frailty and osteoporosis are risk factors of major osteoporotic fractures (MOFs) and associated mortality.；Moreover, hospitalisation is associated with a subsequent increase in frailty, partly due to immobilisation.；Hospitalisation was associated with a higher risk of MOF.；Females had consistently higher MOF rates and, in contrast to males, showed temporary normalisation of MOF cumulative incidence and cause-specific risk at 90 days (HR: 0.93; 0.84-1.03).
局限
（原文未给出可直接抽取的对应表述）
对本项目的价值
人群纵向证据，可用于假说生成与终点选择：功能结局（衰弱 / 肌少症）是临床转化最可及的终点，适合作为一期终点候选。 ｜ 价值分 1.0/5（★☆☆☆☆）
全文来源
未取到全文 → 本卡为摘要级解读，未核验全文
原文题录
- 英文标题：Hospitalisation and subsequent fracture risk-a national matched cohort study in Denmark.
- 期刊与标识：Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · PMID 42963373 · DOI 10.1007/s00198-026-08298-7
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。