时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Respiratory diseases are a leading cause of global morbidity and mortality, imposing a substantial burden on healthcare systems ().；Evidence suggests that pulmonary endothelial cells play an important role in respiratory diseases ().
方法
（全文无独立方法节，正文亦未给出可抽取的实验动作句）
核心结论
Additionally, the AKT/mTOR and HIF-1α signaling pathways are associated with inflammation, whether ESM1 regulates inflammation in lung cancer via these pathways needs to be further explored.；It is reported that serum ESM1 levels are increased due to the downregulation of miR-181a-1 and decreased after treatment (; ; ).；PAH is characterized by the occlusion and stenosis of pulmonary arterioles, leading to increased right ventricular afterload and ultimately triggering right heart failure (; ). ‖ 结论：Accordingly, ESM1 may serve as a potential therapeutic target for respiratory diseases.
局限
全文未设独立 limitations 节；结构上为非 RCT 设计，因果推断强度受限。
对本项目的价值
★☆☆☆☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。
全文来源
PMC JATS 全文（正文 25,162 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The role and mechanism of endothelial cell-specific molecule-1 in respiratory diseases.
- 期刊与标识：Front Physiol · PMID 42953564 · DOI 10.3389/fphys.2026.1914718
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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